摘要
目的:探讨合并用药与丹红注射液安全性的关系,为临床用药提供参考依据。方法:"多中心、大样本"医院集中监测法研究10 409例使用丹红注射液住院患者的合并用药情况,并对相关资料进行挖掘和分析。结果:丹红注射液与化学药物合并使用占用药总数的99.7%,依次为心脑血管疾病用药、神经与精神疾病用药、肠外肠内营养与调节水、电解质、酸碱平衡药、内分泌代谢疾病用药等,丹红注射液不良反应(ADR)与口腔科疾病用药,风湿免疫与骨科疾病用药,肠外肠内营养与调节水、电解质、酸碱平衡药,皮肤科疾病用药存在正相关。结论:丹红注射液ADR与合并用药的种类及数量存在一定相关性,应加强丹红注射液与相关类型药物合并用药的安全性监测。
Objective： To probe into the relationship between combined medication and safety of Danhong injection,and offer a reference for clinical medication.Method： Multi-center and large sample hospital centralized monitoring method was applied to study the combined medication among 10 409 inpatients who used Danhong injection.The related data were mined and analyzed.Result： Among all inpatients investigated,the rate of combined use of Danhong injection and chemical drugs was 99.7%.Drugs frequently combined with Danhong injection were cardiovascular and cerebrovascular medicine,psychotherapeutic drug,enteral and parenteral nutrition and regulation water,electrolyte,acid-base balance drug and endocrine drug.The adverse reactions of Danhong injection positive correlated with stomatological preparation,anti-rheumatic and orthopaedic drug,enteral and parenteral nutrition and regulation water,electrolyte,acid-base balance drug and dermatologic drugs.Conclusion： Adverse reactions of Danhong injection related to the types and quantity of combined drugs.Safety monitoring of Danhong injection should be enhanced when it is combined with other drugs.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第13期294-297,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技部"十一五"重大新药创制子课题(2009ZX09502-030)
关键词
合并用药
丹红注射液
安全性
combined with medication
Danhong injection
safety
