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血管性血友病因子的研究进展 被引量：15

Research Advance in von Willebrand Factor——Review
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摘要 血管性血友病因子(von Willebrand factor,vWF)是由血管内皮细胞和骨髓巨核细胞合成的一种多结构域、多功能糖蛋白,在1期和2期止血中发挥重要作用。vWF缺陷将导致血管性血友病(vWD)等出血性疾病,而在静脉栓塞、血栓性血小板减少性紫癜(TTP)、中风等血栓性疾病中,其活性水平可明显增高。血浆vWF水平与多种影响因素有关。随着近年来对vWF的结构、功能以及活性水平调控机制的了解,人们对于出血与血栓性疾病的病理生理,诊断和治疗有了全面的认识。本文将就血浆vWF活性水平调控与上述疾病关系的研究进展作一综述。 von Willebrand factor（vWF） is a multimeric glycoprotein exclusively synthesized in endothelial cells and megakaryocytes. It plays important roles in the primary and secondary haemostasis. Deficiency or dysfunction of vWF may cause yon Willebrand disease（ vWD）, and overexpression of vWF may cause thrombosis. Making an intensive study on vWF will help us to understand the pathophysiology, diagnosis and treatment of vWF-related diseases, such as vWD, TTP, venous thrombosis, stroke, and so on. In this article, the regulation of vWF activity and its relation with diseases mentioned above are reviewed.
作者 李雪美 江淼 赵益明
机构地区 苏州大学第一附属医院
出处 《中国实验血液学杂志》 CAS CSCD 北大核心 2013年第3期801-805,共5页 Journal of Experimental Hematology
基金 "江苏省临床医学中心(编号ZX201102)"资助
关键词 血管性血友病因子 血管性血友病 血栓性疾病 影响因素 von Willebrand factor von Willebrand disease thrombosis influencing factor
分类号 R554.1 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献41

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二级参考文献17

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共引文献8

同被引文献118

  • 1李树君,金圣宇.血管性血友病因子裂解酶在血栓性血小板减少性紫癜中的作用研究进展[J].延边大学医学学报,2022,45(1):55-59. 被引量：3
  • 2谢飞,王鸿利.血管性血友病因子研究进展[J].国际检验医学杂志,2006,27(7):622-624. 被引量：7
  • 3杨冀萍,刘新峰,吴雅莉,张聪敏.不同栓塞面积肺血栓栓塞症患者血管性假血友病因子及α颗粒膜蛋白-140的变化[J].中国急救医学,2007,27(3):275-277. 被引量：3
  • 4冯洁美,梁勇,马吉联,梁仕兰,陈昌枝,叶少武,朱贵朝.持续气道正压通气对阻塞性睡眠呼吸暂停综合征患者血栓前状态的影响[J].中国医师进修杂志（内科版）,2007,30(10):58-59. 被引量：1
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  • 9Rodrigues SF, Vital SA, Granger DN. Mild hypercholesterolemia blunts the proinflammatory and prothrombotic effects of hypertensionon the cerebral microcirculation [J]. J Cereb Blood Flow Metab, 2013,33 ( 4 ) : 483-489.
  • 10Lee JA, Sunwoo S, Kim YS, et al. Achieving recommended low density lipoprotein cholesterol goals and the factors associated with target achievement of hypercholesterolemia patients with rosuvastatin in primary care[J ]. Curr Med Res Opin, 2013,29 (7) : 751-760.

引证文献15

中国实验血液学杂志
2013年 第3期

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