摘要
目的:检测并分析新生儿ABO溶血病(ABO-HDN)患儿溶血三项试验及其血清总胆红素结果,为临床提供诊治依据。方法:用微柱凝胶卡式法检测ABO溶血三项试验(直接抗球蛋白试验、游离抗体试验、抗体释放试验),按结果类型分为4组:1组:直抗试验(+)、游离试验(+)、释放试验(+);2组:游离试验(+)、释放试验(+);3组:直抗试验(+)、释放试验(+);4组:释放试验(+),并统计各组构成比。用日本OLYMPUS AU-400型全自动生化分析仪测定各组患儿治疗前、后的血清总胆红素水平并比较。结果:237例ABO-HDN患儿中,1组39例(16.45%)、2组116例(48.95%)、3组15例(6.33%)、4组67例(28.27%);1组患儿治疗前的血清总胆红素水平最高,1组>2组>3组>4组,但各组与1组比较差异均无统计学意义(P>0.05);各组治疗后血清总胆红素值均低于治疗前,差异有统计学意义(P<0.05)。结论:及早检测母子ABO血型不合黄疸患儿的溶血三项及其血清胆红素水平有利于临床对ABO-HDN的早期诊断与及时治疗。
Objective：To detect and analyze three hemolysis test and serum total bilirubin,afford diagnosis and therapy basis for ABO haemolytic disease of the newborn（ABO-HDN）.Methods：Microcolumn gel test was used to detect ABO three hemolysis test,including direct antiglobulin test,free antibodies test and antibody releasing test.Groups were divided according to the results into group 1（direct antiglobulin test＋,free antibodies test＋ and antibody releasing test＋）,group 2（free antibodies test＋ and antibody releasing test＋）,group 3（direct antiglobulin test＋ and antibody releasing test＋） and group 4（antibody releasing test＋）.Constituent ratio was compared.Total bilirubin was detected and compared by OLYMPUS AU-400 automatic biochemistry analyzer before and after treatment.Results：There were 39 cases（16.45%） in group 1,116 cases（48.95%） in group 2,15 cases（6.33%） in group 3,67 cases（28.27%） in group 4 among 237 cases of ABO-HDN.The level of total bilirubin in group 1 was highest（group1group 2 group 3 group 4）,but there was no difference among the four groups.The level of total bilirubin of each group was lower after treatment than that of before treatment（P0.05）.Conclusion：Early detection of three hemolysis test and serum total bilirubin of ABO-HDN is benefit to early diagnosis and therapy.
出处
《中国妇幼保健》
CAS
北大核心
2013年第18期2925-2927,共3页
Maternal and Child Health Care of China
关键词
新生儿溶血病
溶血三项试验
血清总胆红素
ABO haemolytic disease of the newborn
Three hemolysis test
Serum total bilirubin
