摘要
目的:观察黄连解毒汤对自发性糖尿病大鼠心肌免疫炎症因子的影响及对心肌损伤的防治作用。方法:GK大鼠30只随机分为GK对照组、二甲双胍组、黄连解毒汤组,正常大鼠10只作为正常对照组分别灌胃12周,测定心肌匀浆核因子-κB(NF-κB)、细胞间黏附分子-1(sICAM-1)、白介素-1(IL-1)、肿瘤坏死因子(TNF-α)、内皮素-1(ET-1)含量。取心肌切片作HE染色。结果:2药物组血糖均下降(P<0.01)。GK对照组各炎症因子升高(P<0.01～0.05),黄连解毒汤组降低(P<0.01～0.05),其中NF-κB、TNF-α、ET-1与二甲双胍比较下降程度较大(P<0.01～0.05)。HE染色显示黄连解毒汤组心肌损伤明显减轻。结论:黄连解毒汤可防治糖尿病心肌炎症损伤。
Objective：The aim is to observe the influence of Huanglianjiedu soup to Spontaneous diabetic rats myocardial immune and inflammatory factors and its prevention and treatment to myocardial injury.Methods： GK rats 30 were randomly divided into the GK control group,the metformin group and Huanglianjiedu decoction group,another 10 rats served as normal controls,they were administered 12 weeks,then determinate the content of myocardial homogenate NF-κB,sICAM-1,IL-1,TNF-α and ET-1.Endomyocardial biopsy were taken for HE staining.Results： Blood glucose of two drugs decreased（P0.01）.Inflammatory factors of GK control group increased（P0.01~0.05）.Huanglianjiedu Decoction group decreased（P0.01~0.05）,Compared with metformin,NF-kappaB,TNF-alpha,ET-1 decreased greater（P0.01~0.05）.HE staining showed myocardial injury significantly reduced of Huanglianjiedu Decoction group.Conclusion： Huanglianjiedu decoction can prevent diabetes myocarditis injury.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2013年第6期634-636,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
山东省优秀中青年科学家基金(博士基金)资助(2005BSB02023)
