摘要
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是高雄激素性不排卵性不孕的最常见原因,在育龄女性中的发生率高达10%。其主要表现为稀发排卵、高雄激素血症或临床高雄激素症状及卵巢呈多囊样改变等。因其临床表现的异质性,迄今为止发病机制尚未完全阐明。然而,高雄激素暴露在PCOS发病过程中所起的关键作用已在世界范围内得到公认,并且近年来的研究强调了胎儿期编程学说和表观遗传学的重要性。综述雄激素在卵巢中的生理功能及其在PCOS发病中可能机制的研究进展。
Polycystic ovary syndrome （PCOS） is the most common cause ot nyperanurogemc anovuxaLmy infertility,with the incidence of 10% among women of reproductive age. The main manifestations include ovulation,hyperandrogenism and polycystic ovary. Since its clinical manifestations are heterogeneous,the etiology of PCOS is still unclear. Nevertheless,the crucial role of hyperandrogenism in PCOS pathogenesis has been recognized in the world. Recently, scientists paid more attention on the early developmental origin hypothesis and epigenetics. We reviewed the role of androgen in ovarian function and its potential mechanism in PCOS pathogenesis.
出处
《国际生殖健康／计划生育杂志》
CAS
2013年第3期194-197,共4页
Journal of International Reproductive Health/Family Planning
基金
国家重大科学研究计划项目(2012CB944900)
"十二五"国家科技支撑计划课题(2012BAI32B04
N20120266-01)
青年科学基金项目(81200485)
关键词
雄激素类
多囊卵巢综合征
胎儿期疗法
遗传学
医学
Androgens
Polycystic ovary syndrome
pathogenesis
Fetal therapies
Genetics, medical
