2Hughes CG, Pandharipande PP. Review articles: the effects of perioperative and intensive care unit sedation on brain organ dysfunction. Anesth Analg,2011,112 (5) : 1212-1217.
3Jason DL,Proudfoot CW, Cann KF, et al. A systematic review of the impact of sedation practice in the ICU on resource use, costs and patient safety. Crit Care,2010,14(2) :1t59.
1Barr J, Fraser GL, Puntillo K,et aLClinical practice guide- lines for the management of pain,agitation,and delirium in adult patients in the intensive care unit[J].Crit Care Med, 2013,41 ( 1 ) : 263-306.
4Pitsiu M, Wilmer A, Bodenham A,et al.Pharmacokinetics of remifentanil and its major metabolite,remifentani- lacid,in patients with renal impairment[J].Br J Anaesth, 2004,92 (4) : 493 -503.
5Dershwitz M,Hoke JF,Rosow CE,et al.Pharmacokineties and pharmacodynamics of remifentanil in volunteer sub- jects with severe liver disease [J].Anesthesiology, 1996, 84(4) :812-820.
