摘要
目的:比较阿司匹林和氯吡格雷治疗老年冠心病疗效及安全性。方法:在中国知网(CNKI)、维普医药信息资源系统(VIP)、万方数据医药信息镜像系统和读秀学术搜索镜像数据库中检索,比较阿司匹林和氯吡格雷治疗老年冠心病疗效及安全性的文献,使用RevMan5.2软件进行Meta分析。结果:共纳入18篇文献进行Meta分析,其中16篇文献报告了安全性结果,12篇文献报告了治疗后血小板聚集率,7篇文献报告了治疗有效率。在安全性分析中,不良反应发生率合并的OR=3.30(P<0.00001),差异有统计学意义,氯吡格雷组更低;在治疗后血小板聚集率分析中,合并的WMD=11.22(P=0.0002),差异有统计学意义,氯吡格雷组更低;在有效率分析中,合并的OR=0.26(P<0.00001),差异有统计学意义,氯吡格雷组更高。结论:对于治疗老年冠心病,氯吡格雷比阿司匹林更有效,不良反应更少,更安全。
Objective： To systematically evaluate the curative effects and safety of treating elderly patients with coronary heart dis- ease on Aspirin and Clopidogrel. Methods： Databases were electronically searched from CNKI, VIP, Wanfang and Duxiu Data, and then RevMan 5.2 was used to undertake Meta analysis. Results： Eighteen trials were included, 16 studies reported safety re- sults, 12 reported platelet aggregation rate （PAG） after treatment,7 reported the efficiency of treatment in the literature, Meta analy- sis showed that： Compared with safety, Clopidogrel was capable of significantly decreasing the incidence of adverse reactions [ OR = 3.30 （P 〈 0. 00001 ） ] ; Clopidogrel was capable of significantly reducing PAG compared with Aspirin [ WMD = 11.22 （ P = 0. 0002） ] ; Clopidogrel was obviously superior to Aspirin in efficacy ~ OR = 0.26 （P 〈 0. 00001 ） ]. Conclusion： The research showed that for the treatment of elderly patients with coronary heart disease, Clopidogrel is more effective than Aspirin, fewer adverse reactions, and appears to be much safer.
出处
《中国药物评价》
2013年第2期100-106,共7页
Chinese Journal of Drug Evaluation
