摘要
目的:探讨血瘀证与血管内皮功能障碍之间的关系。方法 :将受试者分为阴虚热盛证、湿热困脾证、气阴两虚证、阴阳两虚证4组,每组之中再分成兼血瘀证和无血瘀证两个亚组,检测内皮素(ET)、NO、血浆组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活剂抑制物(PAI)、血浆可溶性细胞间黏附分子-1(sICAM-1)。结果 :兼血瘀证者占69.41%,无血瘀证者占30.59%;4个主证型中血瘀证的分布比例无显著性差异(χ2=6.203,P>0.05);兼血瘀证组ET显著大于无血瘀证组(P<0.01),而NO显著小于无血瘀证组(P<0.05);兼血瘀证组t-PA显著小于无血瘀证组(P<0.05),而PAI显著大于无血瘀证组(P<0.05);兼血瘀证组sICAM-1显著大于无血瘀证组(P<0.05)。结论 :血瘀证贯穿于糖尿病始终,且与血管内皮细胞功能障碍具有相关性。
Objective ： To investigate the relationship between blood stasis and vascular endothelial function. Methods ： Subjects were classified into four groups by standard of syndrome differentiation ： group of heat due to yin deficiency, group of dampness-heat stagnating in spleen, group of deficiency of both qi and yin, group of deficiency of both yin and yang.And then subjects were classified into two subgroups by standard of syndrome differentiation again： group with blood stasis and group without blood stasis.The distribution of the two types among the 4 groups was investlgated, and the parameters as ET, NO, t-PA, PAI, sICAM-1 were observed. Results ： The percentage of group with blood stasis was 69.41%, and it was 30.59% for group without blood s＇tasis.Blood stasis existed in all the 4 syndrome groups,Compared with patients without blood stasis, those with blood stasis had higher ET levels （P〈0.01）, lower NO levels （ P〈0.05 ）, lower t-PA levels and higher PAI levels （ P〈0.05 ）, and higher sICAM-1 levels （P〈0.05）. Conclusion ： Blood stasis throughout the course of the type 2 diabetes is associated with endothelial cell dysfunction.
出处
《辽宁中医药大学学报》
CAS
2013年第6期57-59,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然基金资助项目(81072793)
关键词
2型糖尿病
血瘀证
血管内皮功能
黏附分子
type 2 diabetic mellitus
blood stasis syndrome
vascular endothelial function
intercellular adhesion molecule
