摘要
目的探讨克拉霉素预防呼吸机相关性肺炎(VAP)的疗效。方法随机选择2009年1月—2012年3月焦煤集团中央医院呼吸科呼吸急危重病需要机械通气的成年患者206例,采用随机、单盲方法对该206例患者进行试验分组,其中试验组103例患者,对照组103例患者,对照组患者采用常规治疗,而试验组患者在常规治疗的基础上鼻饲克拉霉素0.5g,1次/d。观察并记录VAP发生率,平均机械通气时间和平均住ICU时间。结果试验组和对照组患者中VAP的发生率分别为32%和61%(P<0.05)。试验组平均机械通气时间、平均住ICU时间较对照组明显缩短(P<0.05)。结论克拉霉素鼻饲可显著降低VAP的发生率,缩短机械通气时间和平均住ICU时间。
Objective To study the preventive effect of Clarithromycin on ventilator- associated pneumonia （VAP）. Methods From January 2009 to March 2012, 206 adult patients who needed mechanical ventilation were selected authors hospital. All cases were randomly divided into test group and control group by using single- bhnd method. The test group, contained 103 cases while the other 103 patients were included in the control group. Patients from the control group were treated with conventional therapy, whereas patients from the test group were given the conjoined treatment of conventional therapy and Clarithromycin （0.5g, once daily, nasogastrie）. Then, the VAP incidence, the average duration of mechanical ventilation and ICU stay time were observed and recorded. Results The VAP incidence of the two groups were 32G and 61% respectively, the defference was statistical significant（P〈0.05）. The average duration of mechanical ventilation and the ICU stay time in test group was significantly shorter than those in control croup （P〈0.05）. Conclusion Nasogastric Clarithromycin can reduce the incidence of VAP, the average dura- tion of mechanical ventilation and the ICU stay time significantly.
出处
《中国煤炭工业医学杂志》
2013年第5期728-730,共3页
Chinese Journal of Coal Industry Medicine
关键词
呼吸机相关性肺炎
克拉霉素
抗炎
生物被膜
Vernilator- associated pneumonia
Clarithromycin
Anti - inflammation
Biofilm
