摘要
目的了解我国鲍曼不动杆菌对碳青霉烯类药物的相关耐药机制。方法采用Meta分析方法,分析我国15个省(市)2 354株耐碳青霉烯类鲍曼不动杆菌耐药物机制,主要是产生碳青霉烯酶、外膜蛋白缺失和Ade ABC外排系统3种。结果在淮河以北地区鲍曼不动杆菌耐药基因OXA-51、Int1、OXA-23、OXA-58、IMP及VIM检出率分别为99.4%、97.2%、77.0%、1.6%、1.1%和0.8%,淮河以南地区分别为91.7%、62.8%、78.8%、2.4%、3.5%和1.0%;SIM和OXA-24基因在我国尚无检出报道。外膜蛋白缺失率达91.7%,Ade ABC外排系统检出率为55.4%。结论我国鲍曼不动杆菌耐碳青霉烯类药物机制以外膜蛋白缺失和存在OXA-51、OXA-23基因及Ade ABC外排系统为主,金属酶基因IMP及VIM检出率均很低,SIM和OXA-24基因尚未检出。
Objective To determine the distribution of resistance mechanisms that cause Acinetobacter baumannii to re- sist carbapenems in China. Methods Resistance mechanisms of 2,354 strains of carbapenem-resistant A. baurnannii from 15 provinces and cities in China were subjected to meta-analysis. Major aspects analyzed were carbapenemase pro- duction,outer membrane proteins, and the Ade ABC efflux pump. Results North of the Huai River, A. baumannii was positive for the antibiotic resistance genes OXA-51, Intl, OXA-23, OXA-58, IMP, and VIM at a rate of 99.4%, 97.2%, 77.0%, 1.6%, 1.1%, and 0.8%, respectively, while south of.the Huai River A. baumannii was positive for those genes at a rate of 91.7%, 62.8%, 78.8%, 2.4%, 3.5%, and 1.0%, respectively. SIM and OXA-24 were not de tected. Of the strains, 91.7% had an outer membrane protein deficiency or loss and 55.4% expressed the Ade ABC el- flux pump. Conclusion In China, the primary mechanisms of A. baumannii＇s resistance to carbapenems were the genes OXA-51 and OXA-23, an outer membrane protein deficiency or loss, and the Ade ABC efflux pump. The genes IMP and VIM were detected at very low rates, and SIM and OXA 24 were not detected.
出处
《中国病原生物学杂志》
CSCD
北大核心
2013年第4期358-360,381,共4页
Journal of Pathogen Biology
