摘要
MicroRNAs（miRNAs）作为重要的基因表达调节因子广泛参与发育、凋亡、肿瘤、免疫和机体一微生物相互作用等生理病理过程。miRNAs可对宿主固有免疫和适应性免疫进行精细调控。目前几种常见致病菌（幽门螺旋杆菌、沙门氏菌、李斯特氏菌、分枝杆菌）感染中宿主miRNAs调节免疫应答的相关研究表明，miRNAs在调节宿主抗细菌感染免疫应答中发挥重要作用。明确机体抗感染免疫中miRNAs如何调节免疫应答将有助于开发作用于miRNAs或其靶标的新的治疗手段。
microRNAs （miRNAs） are implicated as important regulators of various physiological as well as pathological processes, including development, apoptosis, cancer, immunity, and host-microorganism interactions, miRNAs can implement a quantitative regulation to innate and acquired immune responses. The current studies on the regulation of host miRNAs in response to infections caused by common bacterial pathogens （Helicobacter pylori, Salmonella enterica, Listeria monocytogenes and Mycobacterium ） illustrate that miRNAs play critical roles in modulating immune responses against bacterial infection. Understanding how the immune response is regulated by miRNAs during infection will facilitate the development of novel therapeutic approaches against pathogenic bacteria.
出处
《国际免疫学杂志》
CAS
2013年第3期182-186,共5页
International Journal of Immunology
基金
2012年北京协和医学院创新基金（2012-1002-022）
