摘要
目的:研究甘草酸(glycyrrhizin,GL)能否防治伊立替康(irinotecan,CPT-11)所致的大鼠迟发性腹泻,并探讨其可能的作用机制。方法:大鼠随机分成4组:正常对照组、GL组、CPT-11腹泻模型组、GL+CPT-11腹泻治疗组。腹泻模型采用连续4天尾静脉(iv)给予CPT-11(80mg·kg-1·d-1)。观察大鼠在静脉给予GL(25 mg·kg-1·d-1)治疗下,腹泻得分、体重等指标变化;同时检测血浆和结肠炎症因子前列腺素E2(PGE2)水平变化。结果:相比CPT-11腹泻模型组,GL+CPT-11腹泻治疗组大鼠提早1天腹泻改善、体重回升,血浆和结肠中PGE2水平也明显低于腹泻模型组。结论:GL对CPT-11诱导的严重迟发性腹泻模型的大鼠有一定的防治作用,其作用机制可能与GL抗炎作用有关。
Objective： To investigate the effect and mechanism of glycyrrhizln （GL） on irinotecan （CPT- 11） provoked late-onset severe diarrhea in rat. Methods： A total of 24 Sprague Dawley male rats were randomly assigned to 4 groups： normal group; GL group, GL was administered at 25 mg·kg-1·d-1 by intravenous injection; delayed-onset diarrhea group, the late-onset severe diarrhea model was formed by intravenous （i.v.） injection of CPT-11 at 80 mg·kg-1·d-1 for 4 days in healthy rats; and GL ＋ delayed-onset diarrhea group. Body weight, diarrhea score and prostaglandin E2 （PGE2） levels in plasma and colon were monitored. Results： CPT-11 induced watery diarrhea, while body weight reduction and changes in PGE2 were counteracted by GL treatment. Conclusion： GL can reduce gastrointestinal toxicity of CPT-11. The possible mechanism is related with anti-inflammatory of GL.
出处
《药学与临床研究》
2013年第2期122-125,共4页
Pharmaceutical and Clinical Research
