摘要
目的 观察缬沙坦联合丹参川芎嗪治疗早期糖尿病肾病（DN）的疗效,寻找有效治疗早期DN的方法。方法 51例早期DN患者按数字表法随机分为两组,治疗组28例采用缬沙坦联合丹参川芎嗪治疗,对照组23例仅接受缬沙坦治疗,检测两组治疗前后的空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、肌酐（Scr）、尿素氮（BUN）、尿微量白蛋白排泄率（UAER）等指标。结果 两组治疗前后FPG、2 h PG、HbA1c、UAER差异均有统计学意义（t=5.361、6.458、3.026、7.894、5.648、7.604、6.590、8.652,均P＜0.05）,两组治疗后2 hPG、HbA1c、UAER差异均有统计学意义（t=3.125、3.520、3.881,均P＜0.05）。两组治疗后BUN、Scr差异均无统计学意义（P＞0.05）。结论 缬沙坦联合丹参川芎嗪治疗早期DN的疗效优于单用缬沙坦,无显著不良反应,可作为临床治疗早期DN的新方法。
Objective To observe the effect of valsartan combined with salvia miltiorrhiza ligustrazine in treating early diabetic nephropathy（DN）,looking for an effective method for the treatment of early DN.Methods 51 DN patients were divided into two groups,28 cases in the treatment group were treated with valsartan and salvia miltiorrhiza ligustrazine therapy,23 cases in the control group only received valsartan treatment.Fasting blood glucose before and after treatment（FPG）,2h postprandial blood glucose（2hPG）,glycosylated hemoglobin（HbA1c）,BUN,Scr,urine albumin excretion rate（UAER） index were detected.Results Before and after treatment,FPG,2hPG,HbA1c,UAER in the two groups had statistically significant differences （t=5.361,6.458,3.026,7.894,5.648,7.604,6.590,8.652,all P〈0.05）.After treatment,2hPG,HbA1c,UAER between the two groups had statistically significant differences （t=3.125,3.520,3.881,all P〈0.05）.No statistical difference was observed before and after treatment in two groups of BUN,Scr （P〉0.05）.Conclusion Valsartan combined with salvia tetramethylpyrazine in treatment of early DN was more effective than single valsartan treatment,and no significant adverse reactions was found in combined treatment.Therefore,the combined treatment can be used as a new method for clinical treatment of early DN.
出处
《中国基层医药》
CAS
2013年第10期1485-1486,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
缬沙坦
丹参川芎嗪
糖尿病肾病
Valsartan
Salvia tetramethylpyrazine
Diabetic nephropathy
