摘要
目的 :研究进口青霉素V钾片在健康人体的药物动力学。方法 :12名健康男性受试者 ,空腹单剂口服进口青霉素V钾片 15 0 0mg ,采用微生物法测定不同时间血清中药物浓度 ,用 3P87软件经微机处理血药浓度 -时间数据。结果 :用药后体内过程符合二房室开放模型 ,其主要药动学参数如下 ,达峰时间 (Tmax)为 (0 70± 0 .11)h ,峰浓度 (Cmax)为 (12 86± 2 2 6 )mg/L ,消除半衰期 (t1/ 2 β)为 (1 2 7± 0 2 4)h ,药时曲线下面积 (AUC)为 (2 0 30±2 90 )mg·h·L-1。结论 :进口青霉素V钾片药动学特点可为临床用药提供参数依据。
Objective To study the pharmacokinetics of penicillin V potassium in Chinese healthy volunteers. Methods 12 male healthy volunteers orally took a single dose of 1500mg penicillin V potassium tablets. The serum concentrations of penicillin V potassium were determined by microbiologic assay. Data of serum level-time were disposed with 3P87 software. Results It demonstrated that the data of penicillim V potassium were fitted to two-compartment open model. The main pharmacokinetic parameters were as follows: T max (0.70±0.11)h,C max (12.86±2.26)mg/L,t 1/2β (1.27±0.24)h,AUC(20.30±2.90)mg·h·L -1 。Conclusion The main pharmacokinetic parameters will be helpful to clinic.
出处
《河南职工医学院学报》
2000年第3期6-6,2,共2页
Journal of Henan Medical College For Staff and Workers
关键词
青霉素V钾片
药物动力学
微生物法
药理
Penicillin V potassium pharmacokinetics microbiologic method.
