摘要
目的探讨奥曲肽联合奥美拉唑治疗肝硬化伴上消化道出血的临床疗效。方法 52例肝硬化合并消化道出血患者为研究对象,随机分为观察组和对照组,各26例。2组患者均常规补充血容量,对照组给予奥美拉唑治疗。观察组在对照组治疗基础上给予奥曲肽治疗。观察2组患者临床疗效,计算平均止血时间、平均住院时间、48 h再出血率及不良反应发生情况。结果观察组临床总有效率为92.3%,明显高于对照组69.2%。观察组平均止血时间、平均住院时间均明显短于对照组,48 h再出血率明显低于对照组。结论奥曲肽联合奥美拉唑治疗肝硬化伴上消化道出血临床效果显著,不良反应发生率低,对于肝硬化合并上消化道出血的临床治疗具有重要意义。
Objective To investigate the clinical effects of octreotide and omeprazole for treating liver cirrhosis accompanied by upper gastrointestinal hemorrhage. Methods Fifty - two patients with liver cirrhosis accompanied by upper gastrointestinal hemorrhage considered as objects of study were randomly divided into observation group and control group, 26 cases in each group. Blood volume of patients in both groups was supplemented. Omeprazole was administered in the control group, while octreotide in the observation group based on the treatment of the treatment group. The clinical effects of patients in both groups were observed, and mean hemostatic time, mean length of hospital stay, reoccurred hemorrhagic rate for 48 h and occurrence of adverse reactions were calculated. Results The total clinical efficacy rate of the observation group was 92.3 %, markedly higher than that of the control group （69.2 % ）. Mean hemostatic time and length of hospital stay of the observation group were significantly shorter than those of the control group, while its reoccurred hemorrhagic rate for 48 h obviously lower than that of the control group. Conclusion In the treatment of liver cirrhosis accompanied by upper gastrointestinal hemorrhage, the combina- tion of octreotide and omeprazole has conspicuous clinical effects, with low incidence rate of adverse reactions, which is of great importance in clinical treatment of liver cirrhosis accompanied by upper gastrointestinal hemorrhage.
出处
《实用临床医药杂志》
CAS
2013年第5期80-82,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11320034)
关键词
肝硬化
上消化道出血
奥美拉唑
奥曲肽
liver cirrhosis
upper gastrointestinal hemorrhage
omeprazole
octreotide
