摘要
目的探讨延边地区女性乳腺癌组织中免疫组化指标COX2、PS2、P53的表达及临床病理指标状况,为早期预防和诊治乳腺癌提供新思路。方法对192例女性乳腺癌患者的有关资料进行统计分析。结果 COX2、P53、PS2的阳性表达率分别为82.81%、45.31%、38.58%。COX2、P53的表达与有关报道差异显著(P<0.01)。COX2与PS2、ER和PR,PS2与年龄、肿瘤大小、ER和PR,P53与病理分期、淋巴结转移等,分别呈显著相关(P<0.05)。淋巴结转移与肿瘤大小、病理分期呈显著正相关(P<0.01),与组织学类型关系密切(P<0.05)。结论本组病例COX2、PS2、P53的表达及其临床病理指标状况,既与有关报道相符,又具自己独立的特点。联合检测和关注这些指标,具有较重要的临床意义。
Objective To analyze expression and clinical pathological conditions of COX2, PS2, P53 in Yanbian fe male breast tissue, offered new direction for early prevention, diagnosis and treatment of breast cancer. Methods Applied retrospective statistical analysis to 192 cases of the female breast pathology data. Results The positive rate of COX2, P53, PS2 was 82.81% ,45.31% and 38.58% respectively. There were significant difference of expression of COX2 and P53 compared with related reports （P〈0.01）. COX2 was significantly related with PS2, ER and PR （P〈0.05）, PS2 was significantly related with age, tumor size, ER and PR （P〈0.05）, P53 was significantly related with tumor size and lymph node metastasis （P〈0.05）. Lymph node metastasis was significantly and positively related with tumor size and pathological stage （P〈 0.01 ）, and it was also related with histological type （P〈0.05）. Conclusion The expression and clinical pathological conditions of COX2, PS2, P53 in the female breast tissue are agreed with the relevant reports, but they also have individual characteristics. There is important clinical significance by joint detection and paying attention to these indicators.
出处
《中国现代医药杂志》
2013年第4期22-25,共4页
Modern Medicine Journal of China
