摘要
目的测定肺结核感染患者血清肿瘤坏死因子-α(TNF-α)与免疫球蛋白E(IgE)的水平,分析其与病情间关系,探讨与预后的相关性,为临床诊治提供依据。方法采用酶联免疫方法测定42例肺结核感染患者治疗前后TNF-α以及用放射免疫方法测治疗前后血清总IgE水平,同时以41例健康体检者作为正常对照。结果在治疗前肺结核感染组血清TNF-α和血清总IgE水平较正常对照组明显升高(P<0.01)。经3个月治疗后肺结核感染组血清TNF-α和血清总IgE水平较治疗前明显降低(P<0.01),但与对照组比较两者仍明显较高,差异有显著统计学意义(P<0.01)。结论 TNF-α可能参与了肺结核感染的发病过程,其与IgE水平的变化与患者病情和预后的关系密切,提示测定TNF-α与IgE水平对肺结核患者的诊断与预后具有一定的临床意义,可据此判断其感染程度,指导临床诊断和治疗。
Objective To determine the level of tumor necrosis factor alpha （ TNF -α） and total IgE in patients of Pulmonary tuberculo- sis, to analyze it~ relation with patients condition and discuss its relationship with prognosis. So as to offer theory basis for clinical diagnosis and treatment. Methods Adopt enzyme - linked immunosorbent assay （ELISA） to measure the level TNF - ct and Radioimmunoassay （RIA） to meas- ure IgE of 42 patients with pulmonary tuberculosis. At the same time chosen 41 healthy physical examination cases as normal control. Results Patients with Pulmonary tuberculosis before treatment of TNF -αand IgE had a significantly higher level than comparing group（ P 〈 0.01 ）. After 3 months treatment TNF -α and IgE of the patients with Pulmonary tuberculosis group were remarkably decreased than that of the before treatment （ P 〈0.01 ） ;but compared with comparing group both distinct high. Discrepancies have obvious statistics significance（ P 〈0.01 ）. Conclusion TNF-α may be involved in Pulmonary tuberculosis development. The Change of TNF-α was closely associated with the seriousness and prog- nosis, which indicates that the level of TNF -α and IgE may be one of parameter to predicted the patients for diagnosis and prognosis, we can ac- cording to the level of TNF -α and IgE to judge the disease severity, it offer important help for diagnosis, therapy and prognosis of diseases.
出处
《临床和实验医学杂志》
2013年第8期595-596,共2页
Journal of Clinical and Experimental Medicine
关键词
肺结核感染
肿瘤坏死因子-Α
IGE
病情
预后
Pulmonary tuberculosis
Tumor necrosis factor - alph
IgE
Seriousness
Prognosis
