摘要
目的观察替米沙坦辅助治疗糖尿病肾病的临床疗效。方法选取本院内分泌科2012年4月～2012年8月住院的糖尿病肾病患者48例,基础治疗:严格控制血脂及血糖,应用胰岛素和(或)口服药物控制血糖达标FBG<7.0 mmol/L,2’PBG<10 mmol/L。48例均接受他汀类降脂药物控制血脂达标、均接受100 mg阿司匹林肠溶片治疗。在此治疗基础上加口服替米沙坦80 mg,1次/d。观察时间为16周。观察舒张压(DBP)、收缩压(SBP)、24 h尿蛋白定量(24 UP)、血肌酐(Cr)、血尿素氮(BUN)、糖化血红蛋白(GHb)。结果治疗前后的DBP、SBP、24 UP、Cr、BUN、GHb较治疗前明显降低,差异均有统计学意义(P<0.05)。结论替米沙坦辅助治疗糖尿病肾病,能够降低尿蛋白、改善肾功能,有效保护肾脏,疗效确切。
Objective To observe the clinical effects of telmisartan in the adjuvant treatment of diabetic nephropathy. Methods 48cases of diabetic nephropathy hospitalized in Endocrine department of LUHE Hospital were selected from April 2012 to August 2012,Basic treatment： blood lipids and blood glucose were strictly controlled： Insulin and （or） oral Antidiabetic drugs were used to obtain the goal of FBG 〈7.0 mmol / L, 2＇PBG 〈10 mmol / L. All of those were received the treatment of statins to obtain the ideal standards of blood lipids, and Aspirin （100 mg） were also use. Besides,Telmisartan（80mg,qd）were added for sixteen weeks. Diastolic Blood Pressure,Systolic Blood Pressure,24-hour Urinary Protein Excretion, Serum Creatinine , Blood Urea and HbAlc Nitrogen were observed. Results Diastolic Blood Pressure,Systolic Blood Pressure,24-hour Urinary Protein Excretion, Serum Creatinine,Blood Urea Nitrogen and HbAlc of post-treatment were decreased significantly.（P〈0.05）. Conclusion The application of telmisartan in the adjuvant treatment of diabetic nephropathy can reduce urinary protein, improve renal function, protecting the kidney effectively.
出处
《湖南中医药大学学报》
CAS
2013年第2期31-32,共2页
Journal of Hunan University of Chinese Medicine
关键词
替米沙坦
糖尿病肾病
治疗
Telmisartan,Diabetic Nephropathy, Treatment
