摘要
目的探讨Wilson病(Wilson's disease,WD)患者神经心理变化特征与中医证型的关系,为辨证论治早期干预WD神经心理功能障碍提供依据。方法对中医辨证符合为肝胆湿热证(31例)、肝肾阴虚证(47例)和气血亏虚证(18例)的96例WD患者进行瑞文标准推理测验(Raven's standard progressive matrices,R'SPM)、Stroop色-字干扰测验(Stroop color-word test,CWT)及连线测验(trail making test,TMT)3项神经心理测验,并分析中医证型积分与3项神经心理测验成绩的相关性。结果 (1)3个中医证型的R'SPM总分、CWT-字义干扰时间、TMT-干扰量比较,差异均有统计学意义(P<0.01,P<0.05)。气血亏虚证的R'SPM总分、CWT-字义干扰时间与肝肾阴虚证、肝胆湿热证比较,差异均有统计学意义(P<0.05);气血亏虚证、肝肾阴虚证TMT-干扰量与肝胆湿热证比较,差异有统计学意义(P<0.05)。(2)3个中医证型积分均与R'SPM总分呈显著负相关(P<0.01)。肝胆湿热证积分与CWT-干扰量呈显著正相关(P<0.01);肝肾阴虚证积分与TMT-B项耗时数、TMT-干扰量呈显著正相关(P<0.05);气血亏虚证积分与CWT-字义干扰时间呈显著正相关(P<0.05)。结论 WD患者神经心理改变与中医证型具有相关性,受损程度气血亏虚证>肝肾阴虚证>肝胆湿热证,虚证严重程度高于实证。
Objective To explore the correlation between neuropsychological features and Chi- nese medical syndrome types in Wilson＇s disease （WD） patients, thus providing evidence for early inter- vention by syndrome typing. Methods Totally 96 WD patients were assigned to Gan-Dan damp-heat syn- drome （GDDHS, 31 cases）, Gan-Shen yin deficiency syndrome （GSYDS, 47 cases）, and qi-blood defi- ciency syndrome （QBDS, 18 cases） by syndrome typing. Three items of neuropsychological testing were performed in them, i.e., Raven＇s standard progressive matrices （R＇SPM）, Stroop color-word test （CWT）, trail making test （TMT）. The correlations between the integrals of Chinese medical syndrome types and results of the 3 tests were analyzed. Results （1） There was statistical difference in the total scores of R＇SPM, the word interference time of CWT, and interference effects of TMT among the 3 syn- drome types （P 〈0.01, P 〈0.05）. There was statistical difference in the total scores of R＇SPM and the word interference time of CWT in patients of QBDS, when compared with those of GDDHS and GSYDS （P〈0.05）. There was statistical difference in interference effects of TMT in patients of GDDHS, when compared with those of QBDS and GSYDS （P 〈0.05）. （2） The integrals of the 3 syndrome types were negatively correlated with the total scores of R＇SPM （P 〈0.01 ）. The integral of GDDHS was significantly positively correlated with the interference effects of TMT （P 〈0.01 ）. The integral of GSYDS was signifi- cantly positively correlated with TMT-B time consumption and interference effects of TMT （P 〈0.05）. The integral of QBDS was significantly positively correlated with the word interference time of CWT （P 〈0.05）. Conclusions There was correlation between neuropsychological changes of WD patients and Chinesemedical syndrome types. The severity of asthenia syndrome was sequenced from high to low as QBDS 〉 GSYDS 〉 GDDHS. The severity of asthenia was higher than that of sthenia.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2013年第3期318-321,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
安徽省卫生厅中医药科研项目(No.2012zy65)
安徽中医学院自然科学基金资助项目(No.2011zr011B)
关键词
WILSON病
肝豆状核变性
神经心理
中医证型
相关性
Wilson＇s disease
hepatolenticular degeneration
neuropsychology
Chinese medical syndrome type
correlation
