摘要
目的:探讨血浆溶血磷脂酸(LPA)在宫颈癌中的表达及临床意义。方法:利用化学比色法检测135例宫颈癌和85例宫颈良性疾病患者及40位健康体检者(对照组)血浆溶血磷脂酸含量,同时采用电化学发光法检测血浆CYFRA21-1含量并作对比分析。结果:宫颈癌组患者血浆LPA水平为(5.11±1.92)μmol/L,明显高于对照组的(2.31±0.45)μmol/L,P<0.01;宫颈良性疾病组患者血浆LPA水平为(2.46±1.05)μmol/L,与对照组比较差异无统计学意义,P>0.05。血浆LPA对宫颈癌诊断的灵敏度和特异度分别为67.4%和97.5%,CYFRA21-1的灵敏度和特异度分别为41.5%和95.0%,LPA均优于CYFRA21-1。血浆LPA和CYFRA21-1在宫颈鳞状上皮癌的表达分别为71.0%和43.5%,均高于腺癌+腺角化癌的27.3%和18.2%,P值均<0.05。宫颈癌晚期(Ⅲ+Ⅳ期)CYFRA21-1阳性率53.2%,明显高于早期(Ⅰ+Ⅱ期)的14.6%;有远处转移的宫颈癌患者血浆LPA阳性率91.9%,明显高于无远处转移者的24.5%,P<0.05。结论:LPA可能与宫颈癌的浸润和转移有关;血浆LPA检测对宫颈癌的诊断及鉴别诊断具有一定的临床应用价值。
OBJECTIVE： To study the plasma lysophosphatidic acid LPA expression in cervical carcinoma and its higher clinical significance. METHODS： Plasma lysophosphatidic acid was detected by using chemical colorimetric assay in 135 eases of cervical cancer and 85 cases benign disease of cervix and 40 healthy people （control group） electrogenerated chemiluminescence was used to detect the concentration of plasma CYFRA21-1 and comparative analysis was made. RE- SULTS： Plasma LPA level in patients with cervical cancer Group （5.11± 1.92） μmol/L was significantly higher than that in control group （2.31±0.45） μmol/L （P〈0.01） ,the benign cervix disease was （2.46±1.05） μmol/L and compared with the control group, the difference was not statistically significant （P〉0.05） ;Plasma LPA on sensitivity and specifici- ty for the diagnosis of cervical cancer were 67.4% and 97.5% respectively, which was better than that of CYFRA21-1 （41.5% and 95.0%）;The expression of LAP and CYFRA21-1 in cervical squamous epithelial cancer were 71.0% and 43.5 %, which was higher than that in adenocarcinoma and cervical adenocancroid （27.3 %, 18.2 %, P〈0.05）. The posi- tive rate of CYFRA21-1 in advanced cervical cancer （stage Ⅲ ＋ Ⅳ） was clearly higher than that in early cases （stage Ⅰ ＋Ⅱ ）, （53.2% vs 14.6%） ;The plasma LPA level in metastatic case was higher than that of no metastatic cases （91.9% vs 24.5% ,P〈0.05）. CONCLUSION： LPA may be associated with cervical cancer invasion and metastasis and detection of plasma LPA is useful in diagnosis and differential diagnosis of cervical cancer.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第3期203-205,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
广西壮族自治区卫生厅计划科研课题(Z2005152)
