摘要
目的 探讨放射性胶体3 2 磷 ( 3 2 P)治疗胰腺癌的疗效。方法 将胰腺癌细胞株SW 1990接种于裸鼠皮下 ,待肿瘤生长直径达 ( 1 2± 0 2 )cm时 ,按每立方厘米瘤体积不同剂量的3 2 P分为空白对照组、5 -FU组、联合组、3 2 P(B)组及3 2 P(A)组进行实验 ,在治疗后 2周测量肿瘤大小 ,计算肿瘤缩小率及肿瘤坏死率。结果 治疗 2周后各组的肿瘤缩小率分别为 - 15 5 19%、12 81%、36 5 7%、44 73%、45 2 0 % (各组与对照组比较P <0 0 5 ) ,肿瘤坏死率分别为 9 12 %、17 6 6 %、2 7 6 4%、45 0 2 %、6 1 72 % (各组与对照组比较P <0 0 5 )。结论 胶体3 2 P肿瘤间质内注射对胰腺癌是一种介入放射肿瘤学有效的治疗方法 ,最佳剂量范围应在 18 5～ 37MBq/cm3 之间 ,临床实验正在逐步进行中。
Objective To assess the effectiveness of colloidal 32 P in the treatment of pancreatic cancer.Methods Pancreatic cancer cells strain SW1990 were inoculated to mouse subcutaneously on their backs.When tumors grew up to the size of (1 2±0 2)cm in diameter,they were treated separately with different doses of 32 P and/or 5-FU.All the mouse were divided into 5 groups according to various treatments received:normal saline group as control,5-FU group,combined group, 32 P(B)group,and 32 P(A)group.After two weeks of treatment,the sizes of tumors were measured,percentage of shrinkage of tumor mass and percentage of necrosis of tumor tissue were calculated.Results After two weeks of treatment the percentage of tumor shrinkage in different groups were -155 19%,12 81%,36 57%,44 73%,and 45 20% (P<0 05,as compared with control group) respectively,and percentage of tumor necrosis in different groups were 9 12%,17 66%,27 64%,45 02%,and 61 72%,respectively (P<0 05 as compared with control group).Conclusion Intratumoral injection with colloidal 32 P is effective in treatment of pancreatic cancer,and the recommended dose is 18 5～37MBq/cm 3.
出处
《中国实用外科杂志》
CSCD
北大核心
2000年第6期356-357,I000,共3页
Chinese Journal of Practical Surgery
基金
福建省卫生厅基金资助
