摘要
研究蛋白质相互作用网络的演化机制及模型对于理解生物系统的进化及组织形成过程具有重要的意义。到目前为止,已经出现了多种依赖不同演化机制的蛋白质相互作用网络演化模型,这些模型有针对性地体现了真实蛋白质相互作用网络中出现的某些拓扑特征,但同时也具有一定的局限性。通过对典型蛋白质相互作用网络演化模型进行研究,从模型的构建机理、演化模型及真实蛋白质相互作用网络的拓扑特征等方面进行了分析和比较,并总结了各个模型的特点。最后,对蛋白质网络演化模型的进一步发展提出了自己的看法,为深入理解蛋白质相互作用网络演化模型提供有益参考。
The research on the evolutional~~ mechanisms and models of Protein-Protein Interaction （PPI） network is significant for understanding the evolution of the biological systems as well as the formation process of the organisms. So far, there have been kinds of models based on different evolutionary mechanisms. All of these models exhibit certain topological characteristics emerging from the protein-protein interaction networks, while some limitations exist simultaneously. This paper focused on several classic protein-protein interaction network models, analyzing the main ideas of these models and comparing the topological characteristics derived from them with those of real protein-protein interaction networks. A summary of the teatures for each model was given based oil the experiments. At last, several viewpoints for the future research of protein- protein interaction network models were also proposed to provide a useful reference for further studies.
出处
《计算机应用》
CSCD
北大核心
2013年第3期816-820,829,共6页
journal of Computer Applications
基金
国家自然科学基金资助项目(60873184
61240046)
湖南省科技计划项目(2011FJ3048)
湖南省财政厅项目(湘财教字[2010]163号)
关键词
蛋白质相互作用网络
演化模型
拓扑特征
Protein-Protein Interaction （PPI） network
evolutionary model
topological characteristic
