摘要
目的探讨血清雌二醇(E2)、甘胆酸(CG)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)测定对妊娠期肝内胆汁淤积症(ICP)的诊断价值及优生意义,并与正常妊娠妇女进行比较。方法分别测定74例妊娠期肝内胆汁淤积症(ICP)和66例正常对照组血清雌二醇、甘胆酸、促甲状腺激素、甲状腺过氧化物酶抗体检测。观察E2、CG、TSH、TPOAb与妊娠期肝内胆汁淤积症的关系。结果与正常妊娠妇女比较,ICP孕妇血清E2、CG、TSH、TPOAb明显升高(P<0.05,或P<0.01)。与轻型ICP孕妇相比,重型ICP孕妇的血清E2、CG、TSH、TPOAb也明显升高(P<0.05,或P<0.01)。结论雌激素参与了ICP病理过程的发生和发展机制。血清CG是目前诊断ICP敏感的血清学指标之一,对ICP的诊断有重要意义。ICP妇女甲状腺功能存在异常,可能参与了ICP的发生及发展。
Objective：To investigate the serum estradiol（E2）,glycocholic acid（CG）,thyroid-stimulating hormone（TSH）,thyroid peroxidase antibody（TPOAb） determination in intrahepatic cholestasis of pregnancy（ICP） in the diagnosis and eugenic significance,and in women with normal pregnancy were compared.Methods： 74 cases of intrahepatic cholestasis of pregnancy（ICP） group and 66 cases of normal control group,serum estradiol,glycocholic acid,thyroid-stimulating hormone and thyroid peroxidase antibodies were measured.Observe the relationship of E2,CG,TSH,TPOAb and gestational intrahepatic cholestasis.Results： Compared with normal pregnant women,the ICP pregnant women serum E2,CG,TSH,TPOAb in significantly higher（P0.05,or P0.01）.Compared with the light ICP pregnant women,the heavy ICP pregnant women serum E2,CG,TSH,TPOAb in significantly higher（P0.05,or P0.01）.Conclusions： Estrogen is involved in the pathogenesis of ICP occurrence and development mechanism.Serum CG is one of the sensitive serum markers in diagnosis of ICP,the diagnosis of ICP has important significance.ICP maternal thyroid function is abnormal,may be involved in the occurrence anddevelopment of the ICP.
出处
《中国优生与遗传杂志》
2013年第2期66-67,共2页
Chinese Journal of Birth Health & Heredity
关键词
妊娠期肝内胆汁淤积症
雌二醇
甘胆酸
促甲状腺激素
甲状腺过氧化物酶抗体
优生意义
Intrahepatic cholestasis of pregnancy
Estradiol
Glycocholic acid
Thyroid stimulating hormone
Thyroid peroxidase antibodies
Healthy birth significance
