摘要
目的:探讨华蟾素联合光动力学疗法(PDT)对荷H22肝癌小鼠胃动素、胃泌素的影响。方法:采用甲脂化叶绿素(MECD)光敏剂联合华蟾素治疗移植性H22肝癌小鼠,测定其抑瘤率及胃动素、胃泌素水平。结果:PDT联合华蟾素组、华蟾素组、PDT组的抑瘤率分别为51.69%、33.49%、26.50%,PDT治疗后可以使胃动素、胃泌素保持在一定的水平,并减轻化疗引起的呕吐、恶心等消化道反应。结论:华蟾素联合光动力学疗法可增强H22肝癌小鼠的杀伤效应,同时能明显改善小鼠整体情况,无明显不良反应和副作用,具有可行意义,值得推荐。
AIM. To discuss the effect of pho todynamic therapy （PDT） combined with anti cancerdrugs cinobufotalin on transplanted H22 liver cancer by observing its influence on moti lin, gastrin. METHODS. The tumor inhibition rate and the levels of gastrin and motilin after Methyl esterification of chlorophyll （MECD） combined with cinobufotalin treating transplanted H22 liver cancer were determined. RESULTS： The inhibitory rate of PDT combined with einobufotalin Group, cinobufotalin Group, PDT Group was 51.69%, 33.49%,26.50%,respectively. The motilin and gastrin were maintained at a certain level treated with PDT, it could reduce digestive tract reaction, such as nausea and vomit. CONCLUSION. Experiments show that PDT combined with cinobufotalin can strengthen obviously photosensitive killing effect on mice transplanted H22 liver cancer, meanwhile,it can improve significantly the overall situation of mice. It has a practical significance and deserves recommendation.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2013年第1期30-33,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省义乌市科技计划项目(2010-43)
