摘要
目的研究丹红合剂对大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量的影响。方法选取健康SD大鼠60只，按照随机数字表随机分为6组，分别为假手术组、模型对照组，采用4血管法造脑缺血再灌注损伤模型，给药组分别给予不同剂量的丹红合剂和复方丹参注射液，观察丹红合剂对大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量的影响。结果丹红合剂高剂量组可降低大鼠急性脑缺血再灌注损伤脑组织含水量（75．84％）及含钙量（114．56μ/g）。丹红合剂中剂量组可降低大鼠急性脑缺血再灌注损伤脑组织含水量（80．13％）；降低大鼠急性脑缺血再灌注损伤脑组织含钙量（132．35μg／g）。丹红合剂低剂量组对大鼠急性脑缺血再灌注损伤脑组织含水量（73．94％）及含钙量（106．32μ/g）有降低趋势，但差异无统计学意义。结论丹红合剂能降低大鼠急性脑缺血再灌注损伤脑组织含水量及含钙量，提示其具有脑保护作用。
Objective To Study the effects of Danhong mixture on water and calcium contents in brain tissue of rats with acute cerebral ischemia reperfusion injury. Methods 60 healthy SD rats were randomly divided into 6 groups, respectively, a sham operation group, a model control group, and 4 drug treatment groups. Models of cerebral ischemia reperfusion injury were established by 4 blood-vessel method, and administrated with different doses of Danhong mixture injection and compound salvia miltiorrhiza injection. Effects of Danhong mixture on water and calcium content in brain tissue of rats with acute cerebral ischemia and reperfusion injury were observed. Results Water and calcium content in brain tissue of rats with acute cerebral isehemia reperfusion injury were significantly decreased in Danhong mixture of high dose group （P〈0.01） , （water was 75.84% and calcium was 114.56 μg/g）. Water and calcium content were also significantly decreased in Danhong mixture of medium dose group （P〈0.01） , （water was 80.13% and calcium was 132.35 μg/g） Water and calcium content showed decreasing tendency in Danhong mixture of low dose group, but without statistical significance, its numerical value was respectively 73.94% and 106.32 μg/g. Conclusion Danhong mixture can reduce water and calcium content in brain tissue of rats with acute cerebral ischemia reperfusion injury, which indicated its neuroprotective effects.
出处
《国际中医中药杂志》
2013年第1期40-42,共3页
International Journal of Traditional Chinese Medicine
关键词
丹红合剂
脑缺血再灌注
含水量
含钙量
Danhong mixture
Cerebral ischemia reperfusion
Moisture content
Calcium content
