摘要
目的:探讨巨细胞病毒(CMV)感染与早产儿支气管肺发育不良(BPD)的关系。方法:选择BPD的早产儿36例(观察组)、非BPD的早产儿40例(对照组),采用ELISA法检测所有受试对象血清CMV-IgM、IgG抗体,辅助检查包括:肝功能、血常规、心肌酶测定及胸部X线摄片,比较两组间CMV感染率以及CMV感染临床症状分类。结果:两组CMV感染率分别为88.89%和67.50%,两组CMV感染率相比有显著性差异(P<0.05)。CMV感染能显著增加支气管肺发育不良的危险3.852倍(95%CI:1.123～13.206)。相对在于无症状性感染,CMV症状性感染能显著增BPD的危险3.194倍(95%CI:1.083～9.423)。结论:巨细胞病毒症状性感染是早产儿支气管肺发育不良的危险因素。
Objective： To investigate the association between eytomegalovirus （CMV） infection and bronchopulmonary dysplasia （BPD） in premature infants. Methods： Serumal antibody of CMV-IgM, IgG in 36 BPD premature infants and 40 premature infants were detected using ELISA method. Auxiliary examinations include hepatic function, blood routine test, myocardial enzyme spectrum and myocardial enzyme spectrum. Amount of CMV infection was compared between the two groups, and the classable of clinical symptoms of CMV infection was analyzed. Results： Compared with control group, BPD group had a higher rate of CMV infection （88.89 % vs 67.50% ）. CMV infection increased the prevalence rate of BPD （OR=3. 852, 95%CI. 1. 123 to 13. 206）. And symptomatic CMV infection increased the prevalence rate of BPD （OR=3. 194, 95%CI： 1. 083 to 9. 423）. Conclusion： The symptomatic retrospective investigation is independently associated with bronchopulmonary dysplasia in premature infants. Suggesting that primary and secondary prevention are crucial elements in improving health for these patients.
出处
《陕西医学杂志》
CAS
2013年第1期27-28,共2页
Shaanxi Medical Journal
关键词
巨细胞病毒感染
并发症
支气管肺发育不良
病因学
免疫球蛋白M
代谢
婴儿
早产
Cytomegalovirus infections/complications Bronchopulmonary dysplasia/etiology Immunoglobulin M/metabolism Infant,premature
