摘要
目的探讨新生儿先天性心脏病患儿的血管紧张素Ⅱ（AngⅡ）．心房利钠肽（ANP）激活状况以及与心力衰竭的关系及其临床意义。方法选取100例新生儿先天性心脏病患儿（NYHA心功能分级Ⅰ级组30例，Ⅱ级组40例以及Ⅲ和Ⅳ级组30例），另选取年龄及性别与之相匹配的正常体检新生儿30名作为对照组，检测AngⅡ、ANP浓度。结果新生儿先天性心脏病患儿血循环中的AngⅡ与对照组比较明显增高，心功能分级3个亚组随着疾病严重程度的加重，AngⅡ的激活就越明显，其中Ⅲ和Ⅳ级组增高最明显[（119．19±5．54）ng／L与（30．72±1．34）ng／L，P〈0．01]；AngⅡ与心功能分级呈明显正相关（r=0．85，P〈0．01）。ANP与对照组比较明显增高，心功能分级3个亚组随着疾病严重程度的加重，ANP的增高越明显，其中Ⅲ和Ⅳ级组增加最明显[（9．00±2．37）pmol／L与（1．15±0．09）pmol／L，P〈0．01]；ANP与心功能分级呈明显正相关（r=0．79，P〈0．01）。结论新生儿先天性心脏病存在AngⅡ及ANP的明显激活，并与疾病的严重程度密切相关；检测AngⅡ及ANP浓度可推测患儿的心功能状况。
Objective To explore the relationship of angiotensin Ⅱ （Ang Ⅱ ） and atrial natriuretic peptide（ANP） with the chronic heart failure syndrome in newborn infant with congenital heart disease. Methods One hundred newborn infant with congenital heart disease（30 patients in cardiac function grade I group;40 patients in cardiac function grade Ⅱ group;30 patients in cardiac function grade Ⅲ and Ⅳ group） were enrolled and 30 cases of nonnal physical examination newborns with matched age and sex were selected as the control group. Concentrations of Ang Ⅱ and ANP were determined in these groups. Results Ang Ⅱ in newborn infant with congenital heart disease were significantly higher than that in normal controls, the activated Ang Ⅱ were more and more as disease severity worsen in the NYHA functional classification subgroup, among them, Ang Ⅱ increased most in grade Ⅲ and Ⅳ group （（119. 19±5.54）ng/L and （30.72±1.34）ng/L,P 〈 0.01）. Ang Ⅱ was significantly correlated with cardiac function classification （r = 0. 85 ,P 〈 0.01 ）. ANP in newborn infant with congenital heart disease were higher than that in normal controls, and ANP also increased more and more obviously as disease severity worsen in the NYHA functional classification subgroup, it increased most in grade Ⅲ and Ⅳ groups （ （ 9.00 ±2. 37 ） pmol/L and （ 1.15±0.09 ） pmol/L, P 〈 0. 01 ）. ANP was significantly correlated with cardiac function classification （r = 0. 79,P 〈 0. 01 ）. Conclusion Ang Ⅱ and ANP are activated in newborn infant with congenital heart disease, they are closely related to the severity of the disease. So the children＇s cardiac function can be soeculated by detecting Ang Ⅱ and ANP concentration.
出处
《中国综合临床》
2013年第1期4-6,共3页
Clinical Medicine of China
基金
广西壮族自治区卫生厅自筹经费科研课题（2008244）
