摘要
目的探讨早期原发性胃弥漫大B细胞淋巴瘤（DLBCL）的预后影响因素及治疗方式的选择。方法回顾性分析天津医科大学附属肿瘤医院1993年1月至2008年8月间经胃镜活检或手术病理证实的75例早期DLBCL患者的临床病理资料。结果75例患者中接受单纯化疗20例．手术联合化疗55例：两组患者完全缓解率分别为65．0％（13／20）和83．6％（46／55），治疗有效率分别为75．0％（15／20）和92．7％（51／55），5年生存率分别为86．9％和78．7％，差异均无统计学意义（均P〉0．05）。单因素和多因素预后分析显示，国际预后指数（IPI）评分是DLBCL患者的独立预后因素（P〈O．05．HR=11．350，95％CI：1．011-127．371）。结论IPI评分是早期胃DLBCL中的独立预后因素：单纯化疗与手术联合化疗的疗效无显著差异。
Objective To explore the prognostic factors and to compare chemotherapy alone versus surgical resection plus chemotherapy for early stage primary gastric diffuse large B-cell lymphomas （DLBCL）. Methods Clinical data of 75 patients who were diagnosed as primary gastric DLBCL between January 1993 and August 2008 in Cancer Institute and Hospital of Tianjin Medical University were reviewed retrospectively. Results Among these 75 patients, 20 patients received chemotherapy alone and 55 underwent surgical resection plus chemotherapy. Complete remission rates were 65.0%（13/20） and 83.6%（46/55）, effective rates were 75.0%（15/20） and 92.7%（51/55）, and 5-year survival rates were 86.9% and 78.7% respectively in chemotherapy alone group and resection plus chemotherapy group, while the differences were not statistically significant （all P〉0.05）. Multivariate Cox regression model showed that international prognosis index （IPI） was the only independent prognostic factor （P〈0.05, HR=11.350, 95%CI：1.011-127.371）. Conclusions In early stage of DLBCL, IPI is the only independent prognostic factor. The clinical outcomes are comparable between chemotherapy alone and surgical resection plus chemotherapy.
出处
《中华胃肠外科杂志》
CAS
CSCD
2013年第1期36-39,共4页
Chinese Journal of Gastrointestinal Surgery
关键词
胃肿瘤
早期
弥漫大B细胞淋巴瘤
化学治疗
外科手术
预后
Stomach neoplasms, early
Diffuse large B-cell lymphomas
Chemotherapy
Surgical procedures
Prognosis
