摘要
目的 探讨小儿肝母细胞瘤的临床病理特点及预后。方法 对 2 4例小儿肝细胞瘤进行临床病理分析和组织学分型 ,其中 18例作 7种标记的免疫组化研究 ;对手术病例进行随访观察。结果 上皮型肝母细胞瘤 2 2例 ,其中胎儿型 13例 ,胚胎型 7例和间变型 3例 ;上皮间叶混合型 2例。细胞角蛋白、甲胎蛋白、S- 10 0蛋白和波型蛋白在肿瘤细胞浆的表达分别为 14例、10例、9例和 4例 ;癌胚抗原、p5 3和 p16蛋白在肿瘤细胞核的表达分别为 11例、9例和 7例。手术完整切除肿瘤 12例中存活 10例 ,8例生存期超过 5年。所有存活病例均为胎儿型。结论 肝母细胞瘤可分为若干组织类型 ,不同类型的免疫表达各异 ,组织类型和预后有关。对胎儿型肝母细胞瘤 ,只要早期诊断和完整切除 ,是可能完全治愈的。
Objective To investigate the clinicopathological characteristics and prognosis of hepatoblastoma in children.Methods The clinicopathological data from 24 cases with hepatoblastoma were analysed,and immunohistochemical study was performed in 18 cases.Results In 22 cases of epithelial subtypes of hepatoblastoma there were 12 cases of fatal type,7 embryonal type,and 3 anapastic type.There were 2 cases of mixed types (epithelial and mesenchymal components).The cytoplasmic positive expression of CK,AFP,S 100 protein and Vimetin of epithelial tumor cells were found in 14,10,9 and 4 cases,respectively.Positive staining of CEA,p53 and p16 of nuclei of epithelial tumor cells were found in 11,9 and 7 cases,respectively.Of 12 cases with surgical resection 8 survived over 5 years .All survived cases were fatal type.Conclusion The histologic subtypes of hepatoblastoma may correlate with prognosis.Hepatoblastoma with fatal subtype may be cured by early diagnosis and complete resection.
出处
《实用肿瘤杂志》
CAS
北大核心
2000年第2期102-104,共3页
Journal of Practical Oncology
关键词
病理学
预后
儿童
肝母细胞瘤
liver neoplasms/pathology
immunohistochemistry
prognosis
child
