摘要
目的了解10年前、后原发性肾小球病的临床病理类型分布及变化的特点。方法收集2001年1月至2002年6月（10年前）以及2011年1月至2012年6月（10年后）行肾穿刺活检并确诊原发性肾小球病患者的资料，对青、中、老年组进行统计分析。结果（1）10年来我科行肾穿刺的中老年人所占比例明显上升。（2）10年前、后临床分型均以慢性肾小球肾炎最常见，其次是。肾病综合征。不同年龄组肾病综合征比例随着年龄增加而上升，慢性肾小球肾炎则相反。（3）IgA肾病、膜性肾病和局灶节段性肾小球硬化均较10年前明显增加。膜性肾病比例随年龄增加呈升高趋势。微小病变则相反。结论10年来行肾穿刺的中老年人所占比例上升，原发性肾小球病临床分型分布无明显变化，病理分型分布发生变化，且不同年龄组病理类型存在差异。
Objective The aim is to investigate the changing clinical and pathological spectrum of primary glomerular disease in the last decade. Methods The records of renal biopsies between Janu- ary 2001 to June 2002（period 1） and January 2011 to June 2012（period 2） were analysed. Then they were divided into 3 groups（groupl ： 18-44 years old, group 2.. 45-64 years old, group 3..65 years of age or older） if they were diagnosed as primary glomerular disease. Results （1）496 and 713 patients had renal biopsies,and the proportion of the middle-aged man rose from 25. 66% to 43. 93% and the elderly,from 3.70% to 9. 93%. （2）The leading primary glomerular disease was chronic glomerulone- phritis in period 1 and 2, followed by nephrotic syndrome. Nephrotic syndrome was more common in older people,while chronic glomerulonephritis was opposite during the same period. （3）IgA nephropa- thy,membranous nephropathy and focal segmental glomerular sclerosis significantly increased com- pared with 10 years ago. Membranous nephropathy was more common in older people in either group, while glomerular minimal change was the opposite. ConclUsions The relative frequency of middle-aged and eldly increased significantly. The clinical spectrum was almost the same in decade while pathological spectrum was different. There were differences pathological types of different age groups.
出处
《临床肾脏病杂志》
2012年第12期545-548,共4页
Journal Of Clinical Nephrology
