摘要
目的探讨核素肾动态显像测定肾小球率过滤(GFR)在宫颈癌患者化疗中的应用价值。方法选择我院2009年1月～2012年4月收治的宫颈癌患者233例,在化疗前及化疗3个周期后应用99锝-二乙三胺五乙酸(99Tcm-DTPA)进行肾动态显像,根据GFR、Tb、C1/2是否超出正常范围为标准,分为异常组70例及正常组163例,分别比较化疗前及化疗3个周期后两组核素肾动态显像结果。结果异常组70例患者化疗3个周期后与化疗前比较GFR明显下降,差异有高度统计学意义(P<0.01),肾动态显像主要特点表现为双肾血流灌注峰值下降,Tb及C1/2延长,差异有统计学意义(P<0.05),而BUN、SCr等指标化疗前后变化均不明显,差异无统计学意义(P>0.05)。结论99Tcm-DTPA肾动态显像可敏感的监测宫颈癌患者化疗后GFR及早期肾功能损伤。
Objective To investigate the application value of the radionuclide renal dynamic imaging in measuring glomeru- lar filtration rate （GFR） in patients with cervical cancer chemotherapy. Methods 233 patients with cervical cancer in our hospital from January 2009 to April 2012 were collected,^99Tc^m-TPA was used in radionuclide renal dynamic imaging be- fore and 3 periods after chemotherapy. According to the value of GFR, Tb, C1/2, 233 cases were divided into 70 cases of abnormal group and 163 cases of normal group, nuclide renal dynamic imaging results were compared in the two groups before and 3 periods after chemotherapy. Results GFR of 70 cases in abnormal group before and 3 periods after chemotherapy were markedly reduced, the difference were statistically significant （P 〈 0.01）; the decline of double renal blood flow perfusion peak and the prolongation of Tb and C1/2 were the main characteristics of renal dynamic imaging, the differences were statistically significant （P 〈 0.05）; the changes of BUN and Scr were not obvious, the differences were not statistically significant （P 〉 0.05）. Conclusion The application value of the radionuclide renal dynamic imaging with ^99Tc^m-DTPA in measuring glomerular filtration rate and early damage of kidney in patients with cervical cancer chemotherapy is sensitive.
出处
《中国医药导报》
CAS
2012年第36期115-116,119,共3页
China Medical Herald
