摘要
去氢枞酸是一种重要的松香衍生物,化学结构中含有苯环及多个手性中心,其衍生物表现出广泛的生物活性,在医药及农药等领域有着重要的用途。根据去氢枞酸的结构特点,通过对羧基进行典型的羧基反应,如酯化、成酰氯、还原成胺、还原成醇及脱羧降解等,以及对芳环进行亲电取代、去异丙基等,合成了一系列具有生物活性的衍生物。主要从羧基改性衍生物生物活性、芳环改性衍生物生物活性两个方面,综述了近几年来去氢枞酸衍生物生物活性研究新进展。
Dehydroabietic acid is an important derivative of rosin. It has benzene ring and several chiral centers, and its deriva- tives exhibit wide range of bioactivities. They have important application in the pharmaceutical and insecticide fields. According to the structural characteristics, a series of bioactive derivatives of dehydroabietic acid were synthesized by typical carboxyl reaction, including esterification, synthesizing acyl chloride, being amine or alcohol by reduction, deearboxylated degradation, and electrophilic substitutions, removing isopropyl from aromatic ring. In this paper, recent advances on biologic activity of dehydroabietic acid derivatives are summarized from two aspects,i, e. carboxyl modification and aromatic modification.
出处
《林产化学与工业》
EI
CAS
CSCD
北大核心
2012年第6期99-106,共8页
Chemistry and Industry of Forest Products
基金
江苏省自然科学基金(BK201112)
关键词
去氢枞酸
衍生物
生物活性
dehydroabietic acid
derivatives
biologic activity
