摘要
目的探讨辅助生殖技术（assisted reproductive technology，ART）受孕的子代新生儿期和远期的体格和神经精神发育状况，以评价ART的安全性。方法选取2006年1月至2011年6月在南京军区福州总医院生殖中心借助ART受孕并成功分娩的孕妇的84例6个月～6岁的儿童作为ART子代组，同期自然受孕者的子代84例作为对照组。χ2或t检验比较2组儿童新生儿期及6个月～6岁时的体格和神经精神发育状况。结果ART子代和自然受孕子代的新生儿期情况（母亲生育年龄、母妊娠合并糖尿病、母妊娠期高血压疾病、分娩方式、居住地、父母受教育程度、出生身长、出生体重、早产、低出生体重、出生窒息、人住新生儿重症监护病房）差异均无统计学意义（P均〉0．05）。ART子代发育迟缓的发生率为6．0％（5／84），社会生活能力有问题的发生率为1．2％（1／84），与自然受孕子代[4．8％（4／84）和1．2%（1／84）]差异无统计学意义（χ2=0．12和0．00，P均〉0．05）。ART子代的发育商与自然受孕子代相比，差异也无统计学意义[（95．9±6．1）分与（94．8±5．1）分，t=1．25，P=0．21]。但双胎儿童较单胎儿童有更高的早产率[41．8％（33／79）与10．1％（9／89），χ2=22．37，OR=6．38，95%CI：2．81～14．50，P=0．00]、低出生体重率[51．9％（41／79）与6．7％（6／89），χ2=42．35，OR=14．93，95％CI：5．84～38．16，P=0．00]、出生窒息率[10．1％（8／79）与1．1％（1／89），χ2=6．69，OR=9．92，95％CI：1．21～81．15，P=0．01]、入住新生儿重症监护病房率[36．7％（29／79）与14．6％（13／89），χ2=10．90，OR=3．39，95％CI：1．61～7．14，P=0．00]和发育迟缓率[11．4％（9／79）与0．0％（0／89），χ2=10．71，RR=10．11，P=0．00]。结论ART似乎没有对子代的体格和神经精神发育状况产生不良影响，但双胎是使早产儿、低出生体重儿、出生窒息、入住NICU、发育迟缓发生率增加的重要因素，需控制ART导致的双胎及多胎妊娠率。
Objective To analysis newborn stage and long-term physiological and neuropsychological development in children born after assisted reproductive technology（ART）, and to evaluate the safety of ART. Methods Eighty-four 6-month-old to 6-yea-old children born after ART performed from January 1st, 2006 to June 30th, 2011 in Reproduction Center of Fuzhou General Hospital were taken as ART group; and 84 matched children born after spontaneous conception were as control group. The physiological and neuropsychological states of these children in their newborn stage and 6 month-old to 6 year-old duration were compared with Chi square or t test. Results There was no statistical difference in childbearing age of mothers, the prevalence of gcstational diabetes mellitus and hypertensive disorder complicating pregnancy, delivery mode, living environment, parents＇ education level, newborn birth length, birth weight, the rate of premature birth, low birth weight, asphyxia and hospitalized to neonatal intensive care unit between two groups （P〉0.05）. In ART group, the incidence of growth retardation and abnormal social life skills was 6.0% （5/84） and 1.2%（1/84）, and no statistical difference were found comparing with control guoup [4.8%（4/84） and 1.2%（1/84）,χ2 =0.12 and 0. 00,P〉0. 05], neither the developmental quotient （95.9±6.1 vs 94.8±5.1,t=1. 25,P=0.21）. Twins had higher rates of preterm birth [41.8%（33/79） vs 10.1%（9/89）, χ2 =22.37, OR：6.38, 95：CI： 2.81-14.50, P=0.00], low birth weight [51.9%（41/79） vs 6.7%（6/89）, χ2=42.35, OR=14.93, 95%CI： 5.84-38. 16, P=0. 001, asphyxia [10.1%（8/79） vs 1.1%（1/89）, χ2=6.69, OR=9.92, 95%CI： 1.21-81.15, P=0. 011, hospitalized to neonatal intensive care unit [36. 7% （29/79） vs 14. 6% （13/89）, χ2=10.90, OR- 3.39, 95%CI： 1.61-7.14, P=0. 00] and growth retardation [11. 4%（9/79） vs 0.0%（0/89）,χ2 = 10.71, RR=0. 11, P 0. 001 than singleton. Conclusions ART has no negative effects on children＇s physical and neuropsychologieal development. It could increase the incidence of twins, so that it might increase the incidences of preterm labor and low birth weight, which might affect the long-term physical and neuropsychological development of the offspring.
出处
《中华围产医学杂志》
CAS
北大核心
2012年第12期710-715,共6页
Chinese Journal of Perinatal Medicine
关键词
生殖技术
辅助
婴儿
新生
儿童
身高
体重
儿童发育
Reproductive techniques, assisted
Infant, newborn
Child
Body size
Body weight
Child development
