摘要
目的研究肝硬化患者抗凝血酶-Ⅲ（AT-Ⅲ）、蛋白C（PC）和蛋白S（PS）的变化及其与终末期肝病评分模型（MELD）的关系。方法选择2010年1月~2011年12月我院住院肝硬化患者116例,检测AT-Ⅲ、D-二聚体（D-dimer）、PC和PS,同时检测凝血酶原国际标准化比值（INR）、血胆红素和血肌酐,计算MELD积分。结果 AT-Ⅲ和PC随MELD积分的增加而降低,D-dimer则随MELD积分的增加而升高,三组间差异有统计学意义（P〈0.05）。AT-Ⅲ和D-dime与MELD积分的相关系数分别为r=-0.343和r=0.257（P〈0.01）。结论肝硬化患者的AT-Ⅲ和D-dimer明显异常且和MELD积分相关,检测AT-Ⅲ和D-dimer有助于判断肝功能严重程度及其预后。
Objective To investigate the relationship between antithrombin-Ⅲ changes and MELD score in patients with liver cirrhosis.Methods From January 2010 to December 2011,a total of 116 cirrhotic patients admitted to our hospital were included in this study.Antithrombin-Ⅲ（AT-Ⅲ）,D-dimer,Protein C（PC）,Protein S（PS）,INR,serum total bilirubin and serum creatinine were test on all patients,and then calculated the MELD score.Results AT-Ⅲ and PC were decreased with MELD score.D-dimer was increased with MELD score.In three groups there were a significant difference（P 0.05）.AT-Ⅲ and D-dimer were found to be related with MELD score（r =-0.343,0.257,P 0.01）.No correlation were found between PC,PS and MELD score.Conclusion AT-Ⅲ and D-dimer have relationship with MELD score in liver cirrhosis patients.The degree of liver function and prognosis could be predicted by these indices.
出处
《中国医药导报》
CAS
2012年第33期52-53,56,共3页
China Medical Herald
