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a-TG、a-TPO与不孕不育关系的研究 被引量：11

Relationship Between a-TG and a-TPO with Infertility
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摘要 目的观察不孕不育妇女的甲状腺抗体水平,通过测定不孕不育女性血清中的抗甲状腺球蛋白抗体(a-TG)、抗甲状腺过氧化物酶抗体(a-TPO)水平,并与100例正常健康人做比较,用以判断甲状腺抗体水平与临床不孕不育的关系。方法采用电化学发光免疫技术测定100例不孕不育女性患者和100名正常健康血清进行a-TG、a-TPO的测定。结果 100例不孕不育女性患者中ATA总阳性率为25%,与正常对照组抗甲状腺抗体(ATA)总阳性率19%相比差异显著,其中抗甲状腺抗体导致反复流产率为16%。结论妇女不孕不育可能与甲状腺抗体水平存在一定的关系。可作为不孕不育病因的检测指标。 Objective To investigate the relationship between serum levels of antithyroglobulin antibody （a-TG） and anti- thyroid peroxidase antibody （ a- TPO） with infertility. Methods The serum levels of a- TG and a- TPO in 100 infertile female patients and 100 normal health controls were determined by electrochemilumineseence immunoassay technology. Results The total positive rate of serum ATA levels in 100 infertile female patients （25%） was significantly higher than that in health controls （19%）. The recurrent spontaneous abortion rate led by higher antithyroid antibodies was 16%. Conclusion Women＇s infertility may be associated with serum thyroid antibodies levels, and they could be used as indexes for detection of infertility etiology.
作者 兰旭青 陈志英
机构地区 解放军第
出处 《标记免疫分析与临床》 CAS 2012年第6期346-348,共3页 Labeled Immunoassays and Clinical Medicine
关键词 抗甲状腺球蛋白抗体 抗甲状腺过氧化物酶抗体 不孕不育 Antithyroglobulin antibodies （ a- TG） Anti- thyroid peroxidase antibodies （ a- TPO） Infertility
分类号 R711.6 [医药卫生—妇产科学]
  • 相关文献

参考文献7

  • 1Stagnaro-Green A, Roman S H, Cobin R H, et al. Detection of at rist pregnancy by means of highly sensitive assays for thyroid Antibodies [J]. JAMA, 1990,264 : 1422 -1425.
  • 2Kutteh W H, Yetman D L, Carr A C, et al. Increased prevalence of antithyroid antibodies identified in women with recurrent pregnancy loss but not in women undergoing assisted reproduction [ J ]. FertilStefil, 1999,71 (5) :843-848.
  • 3Bussem S S, Steck T. Thyroid antibodies and their relation to an- tithrombin antibodies, anticardiolipin antibodies and lupus anticoagu- lant in women with recurrent spontaneous abortions ( antithyroid, anti- cardiolipin and antithrombin autoantibodies and lupus anticoagulant in habitual aborters)[J]. Eur J Obstet Cynecol Reprod Biol, 1997, 74:139-143.
  • 4Lejeune B, Grun J P, de Nayer P, et al. Antithyroid antibodies un- derlying thyroid abnormalities and miscarriage or pregnancy induced hypertension [ J]. Br J Obstet and Gyneeol, 1993,100:669-672.
  • 5Mecacci F, Parretti E, cioni R, et al. Thyroid autoimmunity and its as- sociation. With non-organ-specific antibodies and subclinical altera- tions of thyroid function in women with a history of pregnancy loss or preeclmpsia[ J]. J Reprod Immunol,2000,46( 1 ) :39-50.
  • 6玄英华,刘晶珠,李荷莲.抗甲状腺抗体与反复自然流产关系的研究[J].中国实验诊断学,2006,10(12):1423-1425. 被引量：10
  • 7Iijima T, Tada H, Hidaka Y, et al. Effects of autoantibodies on the course of pregnancy and fetal growh [ J ]. Obstet Gynecol, 1997,90 (3) :364-369.

二级参考文献7

  • 1A Singh,Dantas ZN,Stone SC,et al.Presence of thyroid antibodies in early reproductive failure:biochemical versus clinical pregnancies[J].Fertil Steril,1995,63(2):364.
  • 2W H Kutteh,Yetman DL,Carr AC,et al.Increased prevalence of antithyroid antibodies identified in women with recurrent pregnancy loss but not in women undergoing assisted reproduction[J].Fertil Steril,1999,71(5):843.
  • 3Stagnaro Green A,Roman SH,Coton RH,et al.Detection of at-risk pregnancy by means of highly sensitive assays for thyroid antibodies[J].JAMA,1990,264:1422.
  • 4B Lejeune.Antithyroid antibodies underlysing thyroid abnormalities and miscarriage or pregnancy induced hypertension[J].Br J Obstet and Gynecol,1993,100:669.
  • 5BussemSS,Steck T.Thyroid antibodies and their relation to antithrombin antibodies,anticardiolipin antibodies and lupus anticoagulant in women with recurrent spontaneous abortions(antithyroid,anticardiolipin and antithrombin autoantibodies and lupus anticoagulant in habitual aborters)[J].Eur J Obstet Gynecol Reprod Biol,1997,74:139.
  • 6F Mecacci,Parretti E,Cioni R,et al.Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of pregnancy loss or preeclmpsia[J].J Reprod Immunol,2000,46(1):39.
  • 7Iijima T,Tada H,Hidaka Y,et al.Effects of autoantibodies on the course of pregnancy and fetal prowth[J].Obst & Gynecol,1997,90(3):277.

共引文献9

同被引文献71

  • 1玄英华,刘晶珠,李荷莲.抗甲状腺抗体与反复自然流产关系的研究[J].中国实验诊断学,2006,10(12):1423-1425. 被引量：10
  • 2曹泽毅.中华妇产科学[M].2版.北京:人民卫生出版社,2004:2163-2169.
  • 3Eggert-Kruse W,Reuland M,Johannsen W,et al. Cytomegalovirus(CMV) infection-related to male and /or female infertility factors[J].Fertil Steril,2009,91(1):67-82.
  • 4Mecacci F, Parretti E, Cioni R, et al. Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of preg- nancy loss or preeclampsia[J]. J Reprod Immunol, 2000,46(1): 39-50.
  • 5Lejeune B, Grun JP, de Nayer P, et al. Antithyroid antibodies un- derlying thyroid abnormalities and miscarriage or pregnancy in- duced hypertension[J]. Br J Obstet Gynaecol, 1993,100(7): 669-672.
  • 6Bensenor I. Screening for thyroid disorders in asympto- matic adults from Brazilian populations [J]. Sao Paulo Med J,2002,120(5) :146-151.
  • 7Poppe K, Velkeniers B,Glinoer D. Thyroid disease and fe- male reproduction [J]. Clin Endocrinol (Oxf), 2007, 66 (3) : 309-321.
  • 8王蕊,李春霞,邵幸曙,刘玉梅.女性不孕症患者下生殖道细菌性阴道病感染状况初探[J].中国妇产科临床杂志,2008,9(2):121-123. 被引量：16
  • 9张妮娅,陆卫平,刘影,胡萍,吕述军,刘超.老年糖尿病患者中甲状腺疾病的现患调查[J].医学理论与实践,2008,21(9):1010-1013. 被引量：19
  • 10姜凤伟,凌彩虹,单忠艳,滕卫平,王蓓蓓,王佳妮,赖亚新,陈彦彦.亚临床甲减患者及正常人群血清促甲状腺激素与血压的相关性研究[J].中国实用内科杂志,2009,29(10):906-909. 被引量：11

引证文献11

二级引证文献30

标记免疫分析与临床
2012年 第6期

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