摘要
目的分析龈沟液血管内皮生长因子(VEGF)水平的变化规律与牙周炎活动性的关系。方法选择慢性牙周炎活动期与静止期患者各12例,采用酶联免疫吸附试验检测患牙龈沟液中VEGF的含量并进行比较。结果慢性牙周炎活动期龈沟液含量为(2.192±1.312)μl,静止期龈沟液含量为(1.483±0.781)μl,差异有统计学意义(P<0.05);活动期龈沟液VEGF浓度为(57.831±25.208)mg/L,静止期龈沟液VEGF浓度为(34.039±28.125)mg/L,差异有统计学意义(t=4.03,P<0.05)。结论龈沟液VEGF的水平变化与牙周病变密切相关,有可能成为判断牙周炎进展的生物学标记物。
Objective To analyze the relationship between the levels of vascular endothelial groowth factor（VEGF） in gingival crevicular fluid（GCF） and active phase of periodontitis.Methods Contents of VEGF of 12 patients with teeth in active phase of periodontitis and other 12 patients with teeth in resting phase were detected using enzyme-linked immunosorbent test（ELISA） and the results were compared.Results Contents of GCF in active phase of chronic periodontitis（2.192±1.312） μl was significantly different from that in resting phase（1.483±0.781） μl（P0.05）;significant difference was found in the concentration of VEGF in GCF between the active phase group（57.831±25.208） mg/L and the resting phase group（34.039±28.125） mg/L（t=4.03,P0.05）.Conclusion The level of VEGF in GCF is related to the progression of periodontal disease.It may be useful biological markers for diagnosis of periodontitis.
出处
《临床误诊误治》
2012年第12期58-60,共3页
Clinical Misdiagnosis & Mistherapy
关键词
血管内皮生长因子
龈沟液
牙周炎
慢性
活动性
Vascular endothelial growth factor（VEGF）
Gingival crevicular fluid（GCF）
Periodontitis
chronicity
Activity
