摘要
目的：通过兰州市4家医院协作，包括甘肃省肿瘤医院、兰州大学第二医院、兰州大学第一医院、甘肃省人民医院，对初次住院治疗，并经病理确诊的淋巴瘤患者病理类型进行分析，总结其特点。方法：收集2009年1月2日至2011年6月30日，在兰州市4家医院初次住院治疗的淋巴瘤患者，均进行了病理和免疫组化的确诊，包括淋巴结、淋巴组织器官或骨髓等，对其性别、年龄、病理类型进行分析。结果：330例患者，男189例，女141例，男女之比为1．3：1；年龄分布，41～70岁是个发病高峰。根据2008年WHO淋巴系统恶性肿瘤分类，330例恶性淋巴瘤患者中，霍奇金淋巴瘤54例，占16．4％；非霍奇金淋巴瘤276例，占83．6％，其中B细胞肿瘤201例，占72．8％；T细胞肿瘤75例，占27．2％。201例B细胞肿瘤中，最常见的是弥漫大B细胞淋巴瘤120例，占59．7％；其次是慢性淋巴细胞白血病／小淋巴细胞淋巴瘤25例，占12．4％；结外粘膜相关淋巴组织边缘区B细胞淋巴瘤20例，占10．O％；滤泡淋巴瘤11例，占5．4％；其他类型均≤4％。75例T细胞肿瘤中，最常见的是结外NK／T细胞淋巴瘤，鼻型26例，占34．7％；其次是外周T细胞淋巴瘤，非特异型16例，占21．3％；前体T淋巴母细胞淋巴瘤伯血病16例，占21．3％；其他类型均≤5％。霍奇金淋巴瘤54例中，结节性淋巴细胞为主淋巴瘤2例，占3．7％；结节硬化型霍奇金淋巴瘤13例，占24．0％；混合细胞型霍奇金淋巴瘤15例，占27．8％；富于淋巴细胞的经典型霍奇金淋巴瘤23例，占42．6％；淋巴细胞消减型1例，占1．9％。结论：兰州地区的恶性淋巴瘤在其性别、年龄、病理类型方面有其特点。
Objective：To analyze the feature of distribution pattem of malignant lymphoma pathological subtypes in a multicenter study in initial hospitalization inpatients by 4 hospitals in Lanzhou, including Gansu tumor hospital, the second hospital of Lanzhou university, the first hospital of Lanzhou university and the people＇s hospital of Gansu province. Methods： Malignant lymphoma cases with pathological diagnosis in initial hospitalization inpatients by 4 hospitals in Lanzhou,from Jan 2009 to June 2010, were collected in which their sex,age and pathological subtypes were analysed. Results： 330 patients comprised 189 males and 141 females （with amale to female ratio of 1.3：1 ）, with a high disease age of 41～70 years, according to the new WHO（2008） classification, there were 54 cases （ 16.4% ） of Hodgkin＇s lymphoma （HL） and 276 cases （ 83.6% ） of non-Hodgkin＇s lymphoma （ NHL）.In the 276 NHL cases, B- cell neoplasms accounted for 201 cases （63.9%）and T/NK-cell neoplasms accounted for 75 cases （27.2%）.In 201 B-ceU neoplasms cases,the most common were diffuse large B-ceU lymphoma （120 cases,59.7% ）,chronic lymphocytic leukemia/small lymphocytic lymphoma （25 cases, 12.4% ）, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue （20 cases, 10.0% ）, follicular lymphoma （11 cases,5.4%）, and other classification lymphoma were ≤4%. In 75T/NK-cell neoplasms cases, the most common were extranodal NK/T cell lymphoma of nasal type （26 cases,34.7%）, unspecified peripheral T-cell lymphoma （16 cases, 21.3% ）,T- lymphoblastic leukemia/lymphoma （ 16 cases, 21.3% ）, and other classification lymphoma were ≤ 5%. In 54 Hodgkin lymphoma cases, nodular lymphocyte predominant Hodgkin lymphoma was 2 eases （3.7%）,nodular sclerosis classical Hodgkin lymphoma was 13 cases （24.0%）, mixed cellularity classical Hodgkin lymphoma was 15 cases （27.8%）,lymphocyte-rich classical Hodgkin lymphoma was 23 cases（43.6%） ,lymphocyte-depleted classical Hodgkin lymphoma was 1 case（1.9%）. Conclusion： There is a characteristic distribution pattern of malignant lymphoma in sex, age and subtypes in Lanzhou.
出处
《甘肃医药》
2012年第12期884-887,共4页
Gansu Medical Journal
基金
甘肃省科学技术厅自然科学研究基金计划赞助(项目编号:2009GS01630)
关键词
淋巴瘤
病理类型
malignant lymphoma
subtypes
