摘要
目的探讨新疆哈萨克族高血压与胰岛素抵抗的关系及其影响因素。方法选取2008年5月～2009年5月在新疆玛纳斯县进行流行病学调查的哈萨克族177例为研究对象,以标准法对所有受检者测量血压、身高、体质量、腰围和臀围。根据血压分为哈萨克族对照组和哈萨克族高血压组。血浆葡萄糖采用葡萄糖氧化酶法测定,血浆胰岛素采用放射免疫法测定,血脂各项采用酶标法自动生化分析仪测定。用稳态模式评估法的胰岛素抵抗指数(HOMA-IR)和胰岛素敏感指数(ISI)来评价胰岛素抵抗。结果哈萨克族高血压组较哈萨克族对照组有较高的HOMA-IR值和低水平的ISI值,P<0.05。相关分析也显示哈萨克族HOMA-IR与收缩压、舒张压均呈显著性正相关(P<0.01);多元回归分析表明,体质量指数(BMI)、甘油三酯(TG)对HOMA-IR的影响最大。结论哈萨克族胰岛素抵抗与高血压有着密切的关系。BMI和TG是影响高血压胰岛素抵抗的主要影响因素。
Objective To investigate the relationship between hypertension and insulin resistance and analysis of relative influential factors in Xinjiang Kazak. Methods A total of 177 Kazak adults were collected. Body mass index （ BMI）, blood pressure, waist/hip ratio （WHR）, the triglyceride （TG）, the total cholesterol （TC）, the low-density lipoprotein （ LDL）, the high-density lipeprotein （ HDL）, fasting glucose （FBG） and fasting insulin （FINS） were measured in all cases. Homeostasis model assessment of insulin resistance （HOMA-IR） and insulin sensitive index （ISI） were used to assess insulin resistance. According to the level of blood pressure, those people were divided into normal group and hypertensive group. Results The level of insulin resistance index of Kazak hypertensive group was significantly higher than the normal group, and the level of ISI of Kazak hypertensive group was significantly lower than the normal group （ P 〈 0.05 ）. Levels of systolic blood pressure, diastolic blood pressure were positively correlated with HOMA-IR between Kazak hypertension patients （P 〈0.01 ）. Multiple regression analysis showed that BMI and TG were independent determinants for HOMA-IR. Conclusion There is a close relationship between hypertension and insulin resistance in Xinjiang Kazak.
出处
《山东医药》
CAS
2012年第44期8-10,共3页
Shandong Medical Journal
基金
国家自然科学基金-地区科学基金项目(30760216)
关键词
高血压
胰岛素抵抗
胰岛素抵抗指数
胰岛素敏感指数
hypertension
insulin resistance
insulin resistance index
insulin sensitive index
