摘要
目的 :探讨神经肽 Y( NPY)和神经降压素 ( NT)在原发性高血压 ( EH)发生中的作用及苯那普利降压的可能途径。方法 :利用放射免疫分析 ( RIA)技术对 82例 EH患者苯那普利治疗前后 NPY和 NT含量进行检测。结果 :EH患者血浆 NPY和 NT含量与健康对照组均存在非常显著性差异 ( P<0 .0 1 ) ,血浆NPY与 NT呈密切负相关 ( r=- 0 .651 4,P<0 .0 1 )。 2 4 h动态血压监测显示 ,昼夜节律异常者 (非杓型 )较节律正常者 (杓型 ) NPY浓度明显增高 ,NT则显著降低。苯那普利治疗 8w,EH患者血浆 NPY含量显著下降 ,NT则升高。结论 :神经肽 NPY和 NT参与了高血压病的发生 ,苯那普利可通过降低 NPY和升高 NT水平起到降压作用。
Objective:To investigate the actions of Neuropeptide Y(NPY) and Neurotensin(NT) in the development of essential hypertension(EH),and the possible antihypertensive mechanism of benalapril.Methods:Plasmic NPY and NT were measured with radioimmunoassay in 82 cases of hypertension and 42 normal controls.Results:There were significant difference of plasmic NPY and NT between hypertension patients and normal controls(P<0 01) Plasmic NPY was negatively correlated with NT (r=-0.6514,P<0 01).In reference with the ambulatory blood pressure monitoring ,NPY concentration remarkably increased and NT decreased significantly in patients with abnormal blood pressure rhythm compared with those with normal blood pressure rhythm.After 8 weeks′ treatment with Benalapril,NPY decreased and NT increased significantly in hypertensions.Conclusions: NPY and NT participated in the pathogenesis of hypertension.Benalapril could decrease blood pressure by decreasing NPY and increasing NT.
出处
《山东医科大学学报》
2000年第1期63-65,共3页
Acta Academiae Medicinae Shandong
基金
山东省科委资助课题
