摘要
目的:研究生殖道细菌感染的种类及对妊娠结局的影响。方法:收集2010年3月至2011年9月期间,首次产前检查时间为妊娠16～20周,无内外科合并症,平均年龄30.1岁孕妇。首次产前检查即行阴道分泌物细菌培养,将产妇按照首次产前检查是否存在生殖道细菌培养阳性(指细菌培养有菌生长)分为研究组和对照组,妊娠35～37周再次行生殖道分泌物细菌培养,观察各种带菌状况及处理方法对妊娠结局的影响。结果:(1)妊娠早期、妊娠晚期及新生儿拭子、胎盘拭子细菌培养阳性细菌如下:B族溶血性链球菌,大肠埃希氏菌及粪肠球菌(2)早期生殖道细菌培养阳性且有症状组总体较对照组及无症状组发生感染比率增加,具统计学意义;使用抗生素干预后可以有效减少宫内感染的发生率,具统计学意义。经抗生素干预者,发生新生儿感染机会明显降低,与对照组比较仍有差异,具统计学意义。结论:(1)B族溶血性链球菌生殖道感染是导致严重母儿并发症的主要致病菌,大肠埃希氏菌及粪肠球菌所致妊娠期生殖道感染对母儿亦存在影响;(2)在初次产前检查即需行生殖道分泌物细菌培养,对于有自觉症状者及细菌培养阳性者,进行规范抗生素治疗,可以有效减少母儿并发症发生;分娩后对于生殖道分泌物细菌培养阳性者需使用敏感抗生素预防性用药,并密切注意新生儿情况。
Objective To study the bacterial categories of lower genital tract infection and the effects on pregnant outcomes. Methods The samples for bacterial culture were taken from the pregnant women who, aged 30.1 years, received the first prenatal care at 16-20 weeks of gestation, without internal or surgical complications, from March 2010 to September 2011. The laboratory results were collected and the pregnant outcomes were followed. Results Population distribution were group B streptococcus （GBS）, bacillus coli and enterococcus faecalis which were checked out from lower genital, newborn swabs and placenta swabs. The intrauterine infection rate was higher in the pregnant women with bacterial infection during the early trimester pregnancy than those without infection. If the antibiotics were used, the neonate morbidity was reduced. Conclusions Maternal GBS, bacillus coil and enterococcus faecalis infection in lower genital tract during pregnancy can lead to adverse pregnant outcomes by increasing the incidence of intrauterine infection and neonatal infections. The lower genital discharge could be routinely tested for detecting bacterial category at the first prenatal care.
出处
《实用医学杂志》
CAS
北大核心
2012年第22期3735-3737,共3页
The Journal of Practical Medicine
基金
广东省科技计划项目(编号:2009B03080124)
关键词
生殖道感染
妊娠结局
Lower genital bacterial infection
Pregnant outcome
