期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

蛋白质的核质转位在细胞凋亡及癌变过程中的研究进展 被引量：1

在线阅读 下载PDF
导出
摘要 哺乳动物细胞中存在着数量繁多的可以通过核膜上的核孔复合体在胞核与胞质间进行交换的蛋白质，它们通过核孔复合体在胞核与胞质间进行交换的过程即称为蛋白质的核质转位。这些蛋白可以通过各种转位机制对细胞自身的生长、增殖、
作者 李曼 陈晨 陶泽璋 陈始明 周俊旭
机构地区 武汉大学人民医院耳鼻喉头颈外科
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2012年第10期1272-1276,共5页 Cancer Research on Prevention and Treatment
关键词 凋亡 癌变 核质转位 核孔复合体
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献47

  • 1Chiantore MV, Vannucchi S, Mangino G, et al. Senescence and cell death pathways and their role in cancer therapeutic out- come[J]. Curr Med Chem, 2009, 16 (3) : 287-300.
  • 2Grote P, Schaeuble K, Ferrando May E. Commuting (to) sui- cide:an update on nucleocytoplasmic transport in apoptosis[J]. Arch Biochem Biophys, 2007,462(2) : 156-61.
  • 3Ferrando-May E. Nucleocytoplasmic transport in apoptosis [J]. Cell Death Differ, 2005,12 (10) : 1263-76.
  • 4周鸣,李小玲,李桂源.蛋白质入核转运的机制和研究进展[J].中国生物化学与分子生物学报,2006,22(10):780-786. 被引量：14
  • 5Sorokin AV, Kim ER, Ovchinnikov LP. Nucleocytoplasmic trans port of proteins[J]. Biochemistry ( Mosc), 2007,72 (13) : 1439-57.
  • 6Beck M, Medalia O. Structural and functional insights into nu cleocytoplasmic transport [J ]. Histol Histopathol, 2008, 23 (8) :1025-33.
  • 7Herrmann A, Vogt M, MOnnigmann M, et ah Nucleocytoplas- mic shuttling of persistently activated STAT3 [J]. J Cell Sci, 2007,120(Pt 18) :3249-61.
  • 8Parra M, Mahmoudi T,Verdin E. Myosin phosphatase dephos phorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes [J]. Genes Dev, 2007,21 (6) :638-43.
  • 9Kang Y. Pro-metastasis function of TGFbeta mediated by the Smad pathway[J]. J Cell Biochem,2006,98(6):1380-90.
  • 10Miyazono K. Transforming growth factor-beta signaling in epi thelial-mesenchymal transition and progression of cancer[J]. Proe Jpn Acad Ser B Phys Biol Sci,2009,85(8) :314-23.

二级参考文献51

  • 1Kurz M,Doenecke D,Albig W.Nuclear transport of H1 histones meets the criteria of a nuclear localization signal-mediated process[J].J Cell Biochem,1997,64(4):573-578
  • 2Fahrenkrog B,Aebi U.The vertebrate nuclear pore complex:from structure to function[J].Results Probl Cell Differ,2002,35:25-48
  • 3Rout M P,Aitchison J D,Suprapto A,et al.The yeast nuclear pore complex:composition,architecture,and transport mechanism[J].J Cell Biol,2000,148(4):635-651
  • 4Cronshaw J M,Krutchinsky A N,Zhang W,et al.Proteomic analysis of the mammalian nuclear pore complex[J].J Cell Biol,2002,158(5):915-927
  • 5Ryan K J,Wente S R.The nuclear pore complex:a protein machine bridging the nucleus and cytoplasm[J].Curr Opin Cell Biol,2000,12(3):361-371
  • 6Vasu S K,Forbes D J.Nuclear pores and nuclear assembly[J].Curr Opin Cell Biol,2001,13(3):363-375
  • 7Ribbeck K,Gorlich D.Kinetic analysis of translocation through nuclear pore complexes[J].EMBO J,2001,20(6):1320-1330
  • 8Strawn L A,Shen T,Shulga N,et al.Minimal nuclear porecomplexes define FG repeat domains essential for transport[J].Nat Cell Biol,2004,6(3):197-206
  • 9Zeitler B,Weis K.The FG-repeat asymmetry of the nuclear pore complex is dispensable for bulk nucleocytoplasmic transport in vivo[J].J Cell Biol,2004,167(4):583-590
  • 10Walther T C,Pickersgill H S,Cordes V C,et al.The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import[J].J Cell Biol,2002,158(1):63-77

共引文献13

同被引文献18

  • 1孙兆明,于士柱,安同,周宏旭.GST-NLS(ING1)融合蛋白表达载体构建及表达纯化的研究[J].国际生物医学工程杂志,2006,29(2):69-72. 被引量：4
  • 2王潇,王玉鹏,全宇,纪志梁,陶涛.细胞核质转运受体Importin β家族与转运调控[J].细胞生物学杂志,2006,28(5):637-645. 被引量：3
  • 3Powers M A, Dasso M. Nuclear transport erupts on the slopes of Mount Etna[J]. Nat Cell Biol, 2004,6(2):82-86.
  • 4Kohler M, Ansieau S, Prehn S, et al. Cloning of two novel human importin-α subunits and analysis of the expression pat- tern of the importin-α protein family[J]. FEBS Lett, 1997,417 (1):104-108.
  • 5Gorlich D, Kostka S, Kraft R, et al. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope[J]. Curr Biol, 1995,5 (4):383-392.
  • 6Goldfard D S, Cobett A H, Mason D A, et al. Importin al- pha: a multipurpose muclear-transport receptor[J]. Trends Cell Biol, 2004,14(9):505-514.
  • 7Kotera I, Sekimoto T, Miyamoto Y, et al. lmportin alpha trans- ports CaMKIV to the nucleus without utilizing importin beta [J]. EMBO J, 2005,24(5):942-951.
  • 8Melen K, Fagerlund R, Franke J, et al. Importin alpha nucle- ar localization signal binding sites for STAT1, STAT2, and in- fluenza A virus nucleoprotein[J]. J Biol Chem, 2003,278(30): 28193 -28200.
  • 9Kohler M. Evidence for distinct substrate specificities of im- portin alpha family members in nuclear protein import[J]. Mol Cell Biol, 1999,19(11):7782-7791.
  • 10Harel A, Forbes D J. Importin bata: conducing a much larger cellular symphony[J]. Mol Cell, 2004,16(3):319-330.

引证文献1

二级引证文献1

肿瘤防治研究
2012年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部