摘要
对近年来国内外在原辅料相容性方面的研究进行综述,以便于制剂工作者更好地进行处方设计。笔者首先分析了口服固体制剂原辅料发生不相容的原因,随后对各种原辅料相互作用进行了深入的阐述,并列举了近年来研究的成果;随后对影响原辅料相互作用的外界因素进行了分析和列举;最后对近年来采用的原辅料相容性研究手段进行了综述,为今后更好地开展此类研究提供参考。
To summarize the recently researches of drug-excipients compatibility, in order to help the pharmaceutical dosage formula design. The reasons of the incompatibility of drug-excipients in oral solid dosage forms were analysed at first, then the interactions of drug-excipients were disscused deeply, some research achievements were examplized. The extra-factors which influence the drug-excipients compatibility were disccused. The advanced research methods were summarized to help researches in this field.
出处
《中国现代应用药学》
CAS
CSCD
2012年第9期789-793,共5页
Chinese Journal of Modern Applied Pharmacy
关键词
相容性
研究进展
原辅料
口服固体制剂
compatibility
progress
drug-excipients
oral solid dosage forms
