期刊文献+

入院后首次空腹血糖对急性冠脉综合征患者近期预后的影响 被引量:1

The Effect ofthe First Fasting Glucose after Admission on Prognosis of Acute Coronary Syndrome Patients
在线阅读 下载PDF
导出
摘要 目的检测急性冠脉综合征(ACS)患者入院后首次空腹血糖(FBG)水平,探讨入院后首次FBG水平对ACS患者近期预后的影响。方法 2010-10/2011-04,四川省绵阳市人民医院心内科收治的不伴糖尿病的ACS患者130例。根据入院后首次FBG水平分为A组(≤6.0 mmol/L)、B组(6.1~6.9 mmol/L)、C组(≥7.0 mmol/L),随访并观察3组患者60 d心脏不良事件的发生率,并使用MedCalc软件行ROC分析,探讨FBG对ACS患者近期预后的预测价值。结果随访60 d,3组共发生心脏不良事件11例。A、B、C组的不良事件发生率分别为1.96%、4.26%、25%,3组间两两比较,差异均有统计学意义(P<0.05)。ROC分析显示,FBG作为ACS患者60 d心脏不良事件的预测指标,其准确率可达到81%,95%CI为0.74~0.88。结论随着入院首次FPG水平的升高,ACS患者60 d心脏不良事件的发生率增加。入院后首次FBG可预测ACS患者的近期预后。 Objective To explore the predictive value of FBG as a fast, easy predictor of adverse cardiac e- vents in patients with ACS within 60 days. Methods 130 patients without diabetes mellitus were admitted to our hospital with a diagnosis of ACS from October 2010 to April 2011. According to the first fasting blood glucose ( FBG ), the patients (6. 1 -6.9mmol/L) , C group lowed up for 60 days to observe were divided into three groups: A group (≤ 6. 0mmol/L), B group (≥7.0mmol/L). The patients were treated by regular treatments and fol- incidence of adverse cardiac events. Receiver operator characteristic (ROC) analysis (using MedCalc software) was used to explore the predictive value of FBG. Results Follow-up 60 days in and out of hospital, adverse cardiac events occurred in 1,2, 8 cases in A, B, C group respectively. Theincidence of adverse events in B, C group was higher than that in A group (P 〈 0. 05 ). ROC analysis showed that, as a predictor of 60 -day adverse cardiac events, the accuracy rate of FBG could reach 81% with 95% CI of 0. 74 -0. gg in patients with ACS. Conclusion FBG could predict incidence of adverse car- diac events of ACS patients within 60 days.
作者 张源 李梦芳
出处 《职业卫生与病伤》 2012年第4期237-240,共4页 Occupational Health and Damage
关键词 急性冠脉综合征 入院后首次空腹血糖 预后 acute coronary syndrome the first fasting blood glucose prognosis
  • 相关文献

参考文献16

  • 1Foo K, Cooper J, Deaner A, et al. A single serum glucose measurement predicts adverse outcomes across the whole range of acute coronary syndromes. Heart, 2003, 89(5) :512-516.
  • 2高润霖.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725. 被引量:5093
  • 3柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304. 被引量:2165
  • 4Executive Summary of The Third Report of The National Cho- lesterol Education Program (NCEP) Expert Panel on Detec- tion, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel II1 ). JAMA, 2001, 285 (19) :2486-2497.
  • 5Haffner SM, Lehto S, Ronnemaa T, et al. Mortality from cor- onary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med, 1998, 339(4) :229-234.
  • 6Franklin K, Goldberg RJ, Spencer F, etal. Implications of diabetes in patients with acute coronary syndromes. The Glob- al Registry of Acute Coronary Events. Arch Intern Med, 2004, 154 ( 13 ) : 1457-1453.
  • 7Saad H, Sawan S, Rashed W, et al. Influence of diabetes on the outcome of acute coronary syndrome in Kuwait. Med Princ Pract, 2010,19(2) : 113-117.
  • 8Kadri Z, Danchin N, Vaur L, et al. Major impact of admission glyeae- mia on 30 day and one year mortality in non - diabetic patients admit- ted for myocardial infarction: results from the nationwide French USIC 2000 study. Heart, 2006, 92(7) :910-915.
  • 9Otten R, Kline - Rogers E, Meier DJ, et al. Impact of prc - diabetic state ell clinical outcomes in patients with acute coronary syndrome. Heart, 2005,91 ( 11 ) : 1466-1468.
  • 10Kolman L, Hu YC, Montgomery DG, et al. Prognostic value of ad- mission fasting glucose levels in patients with acute coronary syndrome. Am J Cardiol, 2009, 104(4) :470-474.

二级参考文献24

  • 1李小鹰.阿司匹林在动脉硬化性心血管疾病中的临床应用:中国专家共识(2005)[J].中华心血管病杂志,2006,34(3):281-284. 被引量:194
  • 2Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines(Committee on the Management of Patients With Unstable Angina). J Am Coll Cardiol,2002, 40(7) :1366-1374.
  • 3Bertrand ME, Simoons ML, Fox KA, et al. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J,2002,23 ( 23 ) : 1809 -1840.
  • 4Erhardt L, Herlitz J, Bossaert L, et al. Task force on the management of chest pain. Eur Heart J, 2002, 23 ( 15 ) : 1153-1176.
  • 5CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet, 1996, 348(9038) :1329-1339.
  • 6Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med, 2001 , 345 ( 7 ) :494-502.
  • 7Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet, 2001, 358(9281):527-533.
  • 8Simoons ML, GUSTO IV-ACS Investigators. Effect of glycopmtein Ⅱb/Ⅲa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation:the GUSTO IV-ACS randomised trial. Lancet, 2001,357(9272) :1915-1924.
  • 9Platlat Receptor Inhibitor in Ischemic Syndrome Management(PRISM) study investigator. A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. Platelet Receptor Inhibition in Ischemic Syndrome Management ( PRISM )Study Investigators. N Engl J Med, 1998, 338(21 ) :1498-1505.
  • 10Platlat Receptor Inhibitor in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms(PRISM-PLUS) study investigator. Inhibition of the platelet giycoprotein Ⅱb/Ⅲa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) Study Investigators. N Engl J Med,1998, 338(21) :1488-1497.

共引文献7164

同被引文献13

引证文献1

二级引证文献45

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部