摘要
慢性乙型肝炎是一种严重危害人类健康的疾病。本文主要介绍目前几种以逆转录酶为靶点的抗乙肝病毒常用药物,并结合近年来的研究进展对抗乙肝病毒药物设计的潜在靶点进行讨论。此外,本文还介绍了最近2年内发现的能够在体外有效抑制乙肝病毒复制的化合物,为研究开发新型抗乙肝病毒药物提供参考。
Chronic hepatitis B is a refractory disease which has caused a serious public health problem.This paper mainly introduces several kinds of the current anti-HBV drugs targeting the reverse transcriptase and discusses some potential targets for drug design against HBV based on the recent progress.In addition,this paper summarizes some new compounds reported in recent two years which could potently inhibit the replication of HBV in vitro,in order to provide some information for developing novel anti-HBV drugs.
出处
《国际药学研究杂志》
CAS
2012年第4期280-285,293,共7页
Journal of International Pharmaceutical Research
关键词
乙型肝炎病毒
干扰素
核苷(酸)类
核衣壳
hepatitis B virus
interferon
nucleos（t）ide analogue
nucleocapsid
