摘要
目的探讨妊娠滋养细胞肿瘤的临床特点、诊断及治疗方法,提高妊娠滋养细胞肿瘤的治愈率。方法对新疆医科大学第五附属医院2001年1月-2011年1月诊治的38例妊娠滋养细胞肿瘤患者的临床资料进行回顾性分析。侵蚀性葡萄胎28例,绒毛膜癌10例。根据血HCG、病理、胸片、CT、彩超等检查确诊及发现转移病灶。38例治疗均以化疗为主,其中单纯化疗者27例,化疗联合手术治疗者11例。结果 38例患者共接受148个疗程化疗,手术+化疗及单纯化疗的治疗有效率均为100%,无明显差异(P>0.05);绒癌和侵蚀性葡萄胎的治疗有效率亦无明显差异。结论临床表现结合血HCG检验可早期诊断妊娠滋养细胞肿瘤。化疗是妊娠滋养细胞肿瘤首选和主要的治疗手段,采取以化疗为主、手术治疗为辅的综合治疗手段,可获得满意的治疗效果。
Objective To analyze the clinical features and prognosis of gestational trophoblastic tumor（GTT） following the treatment and to research for the best treatment for different stages of GTT.Methods Thirty eight cases of GTT from January 2001 to January 2011 in Fifth Affiliated Hospital of Xinjiang Medical University were retrospectively studied.28 cases of invasive mole,10 cases of choriocarcinoma.According to the blood HCG,pathology,chest radiograph,CT,and ultrasound to diagnose and find metastatic lesions.38 cases mainly were given the chemotherapy treatment,27 cases were given the pure chemotherapy,others given the chemotherapy treatment combined surgery.Results 38 patients had 148 cycles of chemotherapy,surgery plus chemotherapy and simple treatment response rates are both 100%,have no significant difference（P0.05）.The cure rate of choriocarcinoma and invasive mole had no significant difference.Conclusion GTT should be diagnosed and treated as early as possible.Relatively satisfying effects can be achieved with a comprehensive therapy including chemotherapy and surgery.The effect of chemotherapy on GTT is reliable,it will be better to take general chemotherapy assisted by multiple injection ways.
出处
《新疆医科大学学报》
CAS
2012年第8期1069-1072,共4页
Journal of Xinjiang Medical University
关键词
妊娠滋养细胞肿瘤
绒毛膜癌
侵蚀性葡萄胎
化疗
手术
gestational trophoblastic tumor
choriocarcinoma
invasive mole
chemotherapy
surgery
