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右美托咪定联合芬太尼用于腹腔镜结直肠癌根治术后皮下镇痛 被引量：26

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摘要 目的观察右美托咪定(dexmedetomidine,Dex)联合芬太尼用于腹腔镜结直肠癌根治术后的镇痛效果,并观察其对术后患者睡眠的影响。方法 60例ASAⅠ～Ⅱ级于全身麻醉下行腹腔镜下结直肠癌根治术的患者,术后行患者皮下自控镇痛(PCSA),随机分成3组,每组20例。组1:芬太尼1.0 mg+甲磺酸托烷司琼6 mg;组2:芬太尼0.5 mg+Dex 100μg+甲磺酸托烷司琼6 mg;组3:芬太尼0.5 mg+Dex 200μg+甲磺酸托烷司琼6 mg。分别记录术后2、4、8、24、48 h的动/静疼痛视觉模拟评分(VAS)、恶心呕吐(PONV)的发生率;并利用匹兹堡睡眠质量指数(PSQI)评价患者的睡眠质量。结果组1、组3镇痛效果均满意,需追加镇痛药的比率较组2低(P<0.05);组2、组3的PONV发生率明显低于组1(P<0.05);组3的睡眠各项指标评分及PSQI总分均低于组1及组2(P<0.05),组1与组2差异无统计学意义(P>0.05)。结论 Dex用于腹腔镜肠癌根治术后皮下镇痛,不仅可减少阿片类药物的剂量,还可减少恶心呕吐的发生,提高术后睡眠质量。
作者 李国才 马拥 柳垂亮 钟敏 谢晓澜 魏巍 肖建斌 招伟贤
机构地区 广东省中医院麻醉科
出处 《广东医学》 CAS CSCD 北大核心 2012年第15期2278-2280,共3页 Guangdong Medical Journal
关键词 右美托咪定 芬太尼 术后镇痛 皮下给药
分类号 R735.37 [医药卫生—肿瘤]
  • 相关文献

参考文献9

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共引文献5

同被引文献265

  • 1徐威,张弩,徐文庆.右旋美托咪定在腹腔镜手术患者全麻诱导期的镇静与心血管效应[J].中国老年学杂志,2014,34(1):48-51. 被引量：19
  • 2胡格吉胡,拉布.舒芬太尼静脉与硬膜外自控镇痛在妇科手术后镇痛的临床观察[J].内蒙古医科大学学报,2012,34(S3):283-284. 被引量：2
  • 3孙海燕,黄民,关溯.黄芪总苷对实验性急性胰腺炎的保护作用[J].时珍国医国药,2006,17(10):1980-1981. 被引量：8
  • 4朱华野,朴龙.黄芪提取物抗炎、镇痛、耐缺氧及抗疲劳作用的研究[J].时珍国医国药,2007,18(5):1156-1157. 被引量：39
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引证文献26

二级引证文献280

广东医学
2012年 第15期

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