摘要
目的:观察不同剂量丙种球蛋白治疗川崎病的临床效果。方法:选取笔者所在医院收治的90例川崎病患者,将其随机分为A组和B组,各45例,A组采用丙种球蛋白400mg/kg治疗,B组采用丙种球蛋白1g/kg治疗,其余治疗方法两组均相同。观察两组治疗后临床症状消失时间、总热程、白细胞、C反应蛋白、血沉恢复情况及冠状动脉损害发生率。结果:A组临床症状消失时间明显长于B组,差异具有统计学意义(P<0.05);B组治疗后白细胞、血沉、C反应蛋白较治疗前明显下降,但A组下降不明显,两组差异有统计学意义;B组冠状动脉病变发生率较A组低,差异有统计学意义(P<0.05)。结论:单次大剂量丙种球蛋白治疗川崎病可明显改善临床症状,降低冠状动脉病变发生率。
Objective ： To observe the clinical effect of different doses of gamma globulin in the treatment of Kawasaki disease.Methods ： Selected 90 cases of patients with Kawasaki disease, randomly divided them into group A and group B, with 45 cases in each group, group A took gamma globulin 400 mg/kg for treatment, group B took gamma globulin 1 g/kg for treatment, the rest of the treatment was same in both groups.Observed the time of clinical symptoms disappeared, total duration of fever, leukocyte, C-reactive protein, ESR recovery and the incidence rate of coronary artery lesions of two groups.Results ： The time of chnical symptoms disappeared of group A was significant longer than group B, the difference compared was with statistical significant（P〈O.05）;leukocyte, ESR, C-reactive protein of group B compared with before treatment significantly reduced, bnt the decline of group A was not obvious, the difference was significant of two groups;compared with group A , the incidence rate of coronary artery lesions of group B was low, the difference was significant（P〈0.05）.Conclusion ： Single high dose gamma globulin in the treatment of Kawasaki disease can significantly improve the clinical symptoms, reduce the incidence of coronary artery disease.
出处
《中外医学研究》
2012年第22期12-13,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
不同剂量
丙种球蛋白
川崎病
Different doses
Gamma globulin
Kawasaki disease
