摘要
目的观察麝香保心丸对2型糖尿病(T2DM)合并慢性收缩性心力衰竭患者心功能和血浆脑钠肽(BNP)水平的影响。方法纳入78例T2DM合并慢性收缩性心力衰竭患者,随机分为常规治疗组(对照组,n=38)和常规治疗+麝香保心丸组(观察组,n=40),治疗6个月后观察临床总有效率,6min步行试验和血浆BNP浓度以及心功能超声检查各项参数的改善情况。结果观察组总有效率90.0%,对照组总有效率78.9%,两组比较差异有统计学意义(P<0.05)。治疗后两组血浆BNP浓度均值较治疗前均有下降,但观察组下降较对照组更加明显(P<0.05)。6min步行试验运动耐量观察组较对照组增强(P<0.05)。两组治疗后心功能各项参数较治疗前均有改善(P<0.05);而治疗后观察组心功能指标改善较对照组更加明显,差异有统计学意义(P<0.05～0.01)。结论麝香保心丸能显著提高T2DM合并慢性收缩性心力衰竭患者的运动耐量,降低血浆BNP浓度,改善心功能。
Objective To observe the influences of Shexiang Baoxin Wan on cardiac function and B-type natriuretic peptide （BNP） in patients with type 2 diabetes mellitus （T2DM） complicating chronic systolic heart failure. Meth- otis The patients with T2DM complicating chronic systolic heart failure （n = 78） were selected and randomly divided into control group （ n = 38, treated with routine therapy） and observation group （ n = 40, treated with routine therapy and Shexiang Baoxin Wan）. Afier 6 months,the total effective rate,6-minute walk distance test （6MWD） ,plasma BNP lev- el, and ultrasonography parameters of cardiac function were observed. Results The total effective rate was 90.0% in observation group and 78.9% in control group （ P 〈 0.05 ）. The level of plasma BNP decreased in two groups after the treatment, which was more significant in observation group （ P 〈 0.05 ）. 6MWD was improved in observation group compared with control group （ P 〈 0.05 ）. The ultrasonography parameters of cardiac function were improved in two groups after the treatment （P 〈 0.05 ） ,while the improvement of cardiac function indexes was more significant in obser- vation group compared with control group （ P 〈 0.05 to P 〈 0.01 ）. Conclusion Shexiang Baoxin Wan can signifi- cantly increase exercise tolerance, reduce the level of plasma BNP and improve cardiac function in the patients with T2DM complicating chronic systolic heart failure.
出处
《中国循证心血管医学杂志》
2012年第3期234-236,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
麝香保心丸
慢性收缩性心力衰竭
心功能
脑钠肽
6分外步行试验
Shexiang Baoxin Wan
Chronic systolic heart failure
Cardiac function
B-type natriuretic peptide
6-minute walk distance test
