摘要
目的检测急性脑出血患者血清中血管内皮生长因子（VEGF）和c．反应蛋白（CRF）的含量并分析其临床意义。方法选取广东省高州市中医院脑病科自2008年8月至2011年8月收治的78例急性脑出血患者（轻度39例，中度25例，重度14例）作为研究组，同期体检中心的78例健康体检者作为对照组．分别采用酶联免疫吸附实验（ELISA）法和免疫比浊法检测2组血清中VEGF、CRP的含量并进行比较分析。结果研究组患者血清中VEGF和CRP的含量均明显高于对照组，而且重度、中度、轻度急性脑出血患者血清中vEGF和CRP的含量依次减低，差异均有统计学意义（P〈0．05）。研究组患者治疗后死亡16例，存活62例，死亡患者血清中VEGF和CRP的含量明显高于生存患者，差异有统计学意义（氏0．05）。结论急性脑出血患者血清中VEGF和CRP的含量明显升高，且该两指标可用于辅助判断急性脑出血的病情严重程度与预后。
Objective To investigate the serum levels of vascular endothelial growth factor （VEGF） and C-reactive protein （CRP） in patients with acute intra-cerebral hemorrhage and explore their significance. Methods Seventy-eight patients with acute intra-cerebral hemorrhage （the mild, n=39; the moderate, n=25; and the severe, n=14）, treated in our hospital fxom August 2008 to August 2011, were selected in this research, and 78 healthy controls received healthy examination at the same time were also selected. Enzyme-linked immunoassay （ELISA） was used to detect the serum level of VEGF, while immunoturbidimetry was used to detect the serum level of CRP. Results The levels of VEGF and CRP of acute intra-cerebral hemorrhage patients were all significantly higher than those of healthy persons （P〈0.05）; VEGF and CRP serum levels in severe, were decreased in turn with significant difference （/9〈0.05）. And VEGF and CRP serum levels of dead patients （n=16） were also significantly higher than those of survive patients （n=62, P〈0.05）. Conclusion VEGF and CRP serum levels of acute intra-cerebral hemorrhage patients are significantly higher than those of healthy persons, and they all have strong positive relationship with the severity and prognosis of the disease.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2012年第8期812-814,共3页
Chinese Journal of Neuromedicine
关键词
急性脑出血
VEGF
CRP
Acute intra-cerebral hemorrhage
Vascular endothelial growth factor
C-reactive protein
