摘要
目的探讨缬沙坦对心脏X综合征患者血清一氧化氮(NO)、内皮素-1(ET-1)及内皮依赖性血管舒张功能的影响。方法 36例心脏X综合征患者给予缬沙坦80mg,1次/d,随访治疗12周,另入选同期健康体检者26例。复查心脏X综合征患者治疗前后NO、ET-1及血流介导的肱动脉内皮依赖性血管舒张功能(FMD)及运动平板试验的变化。结果用药12周后,与治疗前比较,心脏X综合征患者的NO上升和FMD提高(P<0.05);ET-1降低和最大ST段压低幅度明显降低(P<0.05);运动总时间、ST段压低1mm时间明显延长。结论缬沙坦可改善血管内皮功能,并提高患者的运动耐量。
Objective To explore the effect of valsartan capsules on serum nitric oxide （NO）, endothelin - 1 （ ET - 1 ） and vascular endothelial function in patients with cardiac syndrome X. Methods Thirty six patients with cardiac syn-drome X were enrolled and treated with valsartan capsules 80 mg, qd for 12 weeks. 26 case healthy subjects were served as con- trol group. Results of vascular endothelial function （ FMD）, the levels of nitric oxide （NO） and endothelin - 1 （ ET - 1 ）, treadmill tests, were determined before and after treatment. Results After 12 weeks treatment, the serum level of NO and FMD significantly increased （ P 〈 0. 05 ） ; ET - 1 and ST depression significantly decreased （ P 〈 0.05 ） ; Total exercise duration and time, when ST segment depression shorten 1 mm were significantly longer （ P 〈 0. 05 ）. Conclusion Valsartan capsules can improve vascular endothelial function and exercise tolerance in patients with cardiac syndrome X.
出处
《实用心脑肺血管病杂志》
2012年第8期1298-1299,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
缬沙坦
心脏X综合征
内皮
血管
一氧化氮
内皮素-1
Va｜sartan Capsules
Cardiac syndrome X
Endothelial, vascular
Nitric oxide
Endothelin -1
